PDF(Pubmed)
Abstract：
BACKGROUND: Actinic keratosis (AK), or solar keratosis, is a precancerous condition of the skin, mainly caused by excessive and chronic exposure to ultraviolet radiation. Pigmented AK (pAK) is a rare variant of AK. Photodynamic therapy (PDT) is widely used to treat the classical variant of AK, but very limited data are available on the use of PDT in patients with pAK. The objective of this study was to assess the usefulness of PDT in the treatment of pAK.
METHODS: The study included 16 patients with 20 pAK lesions treated with PDT. All skin lesions were clinically and dermatoscopically assessed for typical features characteristic of pAK. Reflectance confocal microscopy (RCM) was also used to assess keratinocyte atypia, confirm pAK diagnosis, and rule out other disease entities.
RESULTS: After three PDT sessions, the complete resolution of all clinical features of pAK was observed in 80% of the studied lesions. Dermatoscopically, 65% of the lesions achieved 100% response and no cellular atypia was seen in the follow-up RCM images of 85% of lesions.
CONCLUSIONS: Photodynamic therapy is an effective treatment modality for pAK in fair-skinned individuals.
METHODS: The study included 16 patients with 20 pAK lesions treated with PDT. All skin lesions were clinically and dermatoscopically assessed for typical features characteristic of pAK. Reflectance confocal microscopy (RCM) was also used to assess keratinocyte atypia, confirm pAK diagnosis, and rule out other disease entities.
RESULTS: After three PDT sessions, the complete resolution of all clinical features of pAK was observed in 80% of the studied lesions. Dermatoscopically, 65% of the lesions achieved 100% response and no cellular atypia was seen in the follow-up RCM images of 85% of lesions.
CONCLUSIONS: Photodynamic therapy is an effective treatment modality for pAK in fair-skinned individuals.
摘要：
背景：光化性角化病（AK），或者日光性角化病，是皮肤的癌前病变,主要由过度和长期暴露于紫外线辐射引起。色素AK（pAK）是AK的罕见变体。光动力疗法（PDT）被广泛用于治疗AK的经典变体，但是关于PDT在pAK患者中的应用的数据非常有限.这项研究的目的是评估PDT在治疗pAK中的有用性。
方法：该研究包括16例PDT治疗的20个pAK病变患者。所有皮肤病变均在临床和皮肤镜下评估pAK的典型特征。反射共聚焦显微镜（RCM）也用于评估角质形成细胞异型，确认pAK诊断，并排除其他疾病实体。
结果：在三个PDT会话之后，在80%的研究病灶中观察到pAK所有临床特征的完全缓解.皮肤科检查,65％的病变达到100％的反应，并且在85％的病变的后续RCM图像中未发现细胞异型。
结论：光动力疗法是治疗皮肤白皙个体pAK的有效方法。
方法：该研究包括16例PDT治疗的20个pAK病变患者。所有皮肤病变均在临床和皮肤镜下评估pAK的典型特征。反射共聚焦显微镜（RCM）也用于评估角质形成细胞异型，确认pAK诊断，并排除其他疾病实体。
结果：在三个PDT会话之后，在80%的研究病灶中观察到pAK所有临床特征的完全缓解.皮肤科检查,65％的病变达到100％的反应，并且在85％的病变的后续RCM图像中未发现细胞异型。
结论：光动力疗法是治疗皮肤白皙个体pAK的有效方法。
