Abstract:
Iron-sulfur (Fe-S) clusters are ancient protein cofactors ubiquitously exist in organisms. They are involved in many important life processes. Plastids are semi-autonomous organelles with a double membrane and it is believed to originate from a cyanobacterial endosymbiont. By learning form the research in cyanobacteria, a Fe-S cluster biosynthesis and delivery pathway has been proposed and partly demonstrated in plastids, including iron uptake, sulfur mobilization, Fe-S cluster assembly and delivery. Fe-S clusters are essential for the downstream Fe-S proteins to perform their normal biological functions. Because of the importance of Fe-S proteins in plastid, researchers have made a lot of research progress on this pathway in recent years. This review summarizes the detail research progress made in recent years. In addition, the scientific problems remained in this pathway are also discussed.
摘要:
铁-硫(Fe-S)簇是普遍存在于生物体内的古老的蛋白质辅因子。他们参与了许多重要的生命过程。质体是具有双层膜的半自主细胞器,据信起源于蓝细菌内共生体。通过学习蓝藻的研究,Fe-S簇生物合成和递送途径已被提出并部分在质体中得到证实,包括铁的摄取,硫动员,Fe-S团簇组装和交付。Fe-S簇对于下游Fe-S蛋白执行其正常生物学功能是必不可少的。由于Fe-S蛋白在质体中的重要性,近年来,研究者对该途径取得了大量的研究进展。本文综述了近年来取得的详细研究进展。此外,还讨论了这一途径中仍然存在的科学问题。