PDF(Pubmed)
Abstract：
The interaction between bacteria and insects can significantly impact a wide range of different areas because bacteria and insects are widely distributed around the globe. The bacterial-insect interactions have the potential to directly affect human health since insects are vectors for disease transmission, and their interactions can also have economic consequences. In addition, they have been linked to high mortality rates in economically important insects, resulting in substantial economic losses. MicroRNAs (miRNAs) are types of non-coding RNAs involved in regulating gene expression post-transcriptionally. The length of miRNAs ranges from 19 to 22 nucleotides. MiRNAs, in addition to their ability to exhibit dynamic expression patterns, have a diverse range of targets. This enables them to govern various physiological activities in insects, like innate immune responses. Increasing evidence suggests that miRNAs have a crucial biological role in bacterial infection by influencing immune responses and other mechanisms for resistance. This review focuses on some of the most recent and exciting discoveries made in recent years, including the correlation between the dysregulation of miRNA expression in the context of bacterial infection and the progression of the infection. Furthermore, it describes how they profoundly impact the immune responses of the host by targeting the Toll, IMD, and JNK signaling pathways. It also emphasizes the biological function of miRNAs in regulating immune responses in insects. Finally, it also discusses current knowledge gaps about the function of miRNAs in insect immunity, in addition to areas that require more research in the future.
摘要：
细菌和昆虫之间的相互作用可以显着影响广泛的不同领域，因为细菌和昆虫广泛分布在全球各地。细菌-昆虫相互作用有可能直接影响人类健康，因为昆虫是疾病传播的媒介，它们的相互作用也会产生经济后果。此外,它们与经济上重要的昆虫的高死亡率有关，造成了巨大的经济损失。微RNA(miRNA)是参与转录后调控基因表达的非编码RNA类型。miRNA的长度范围为19至22个核苷酸。MiRNAs,除了表现出动态表达方式的能力外，有各种各样的目标。这使它们能够控制昆虫的各种生理活动，比如先天免疫反应。越来越多的证据表明，miRNAs通过影响免疫反应和其他耐药机制在细菌感染中具有至关重要的生物学作用。这篇综述集中在近年来取得的一些最新和令人兴奋的发现，包括细菌感染背景下miRNA表达失调与感染进展之间的相关性。此外，它描述了它们如何通过靶向Toll来深刻影响宿主的免疫反应，IMD,和JNK信号通路。它还强调了miRNA在调节昆虫免疫反应中的生物学功能。最后,它还讨论了目前有关miRNA在昆虫免疫中的功能的知识差距，除了未来需要更多研究的领域。
