Abstract：
The monoclonal B-cell lymphocytosis (MBL) introduced as new entities in the 2008 WHO classification, are defined by circulating B-cell clone < 5.109/L without organomegaly and previous and/or simultaneous lymphoproliferative disorders. The MBL were subclassified in MBL CLL type (the most frequent), MBL atypical CLL type and MBL non-CLL type (rarely reported in literature). Here the clinic, cytologic, immunologic and genetic features of MBL non-CLL type were described from a series of 34 cases. As previously reported, present cases presented immunologic and genetic similarities to MZL and could be associated to the new proposed entity CBL-MZ (clonal B-cell lymphocytosis of marginal zone origin). In addition, few cases presented similarities to splenic diffuse red pulp lymphoma (SDRPL). In conclusion, according to the literature, MBL with non-CLL type (assimilated to CBL-MZ) may be a premalignant state of MZL and/or SDRPL.
摘要：
单克隆B细胞淋巴细胞增多症（MBL）在2008年WHO分类中作为新实体引入，定义为循环B细胞克隆<5.109/L，没有器官肿大和先前和/或同时发生的淋巴增殖性疾病。MBL被细分为MBLCLL类型（最常见），MBL非典型CLL型和MBL非CLL型（文献报道较少）。这里是诊所，细胞学,从34例病例中描述了MBL非CLL型的免疫学和遗传学特征。正如以前报道的那样，本病例与MZL具有免疫学和遗传相似性,可能与新提出的实体CBL-MZ(边缘区起源的克隆B细胞淋巴细胞增多症)相关.此外,少数病例与脾弥漫性红髓淋巴瘤（SDRPL）相似。总之,根据文献,具有非CLL型(与CBL-MZ同化)的MBL可能是MZL和/或SDRPL的恶化前状态。
