PDF(Pubmed)
Abstract：
In the sulfotransferase (SULT) superfamily, members of the SULT1 family mainly catalyse the sulfonation reaction of phenolic compounds, which is involved in the phase II metabolic detoxification process and plays a key role in endocrine homeostasis. A coding variant rs1059491 in the SULT1A2 gene has been reported to be associated with childhood obesity. This study aimed to investigate the association of rs1059491 with the risk of obesity and cardiometabolic abnormalities in adults. This case‒control study included 226 normal weight, 168 overweight and 72 obese adults who underwent a health examination in Taizhou, China. Genotyping of rs1059491 was performed by Sanger sequencing in exon 7 of the SULT1A2 coding region. Chi-squared tests, one-way ANOVA, and logistic regression models were applied. The minor allele frequencies of rs1059491 in the overweight combined with obesity and control groups were 0.0292 and 0.0686, respectively. No differences in weight and body mass index were detected between the TT genotype and GT + GG genotype under the dominant model, but the levels of serum triglycerides were significantly lower in G-allele carriers than in non-G-allele carriers (1.02 (0.74-1.32) vs. 1.35 (0.83-2.13) mmol/L, P = 0.011). The GT + GG genotype of rs1059491 versus the TT genotype reduced the risk of overweight and obesity by 54% (OR 0.46, 95% CI 0.22-0.96, P = 0.037) after adjusting for sex and age. Similar results were observed for hypertriglyceridaemia (OR 0.25, 95% CI 0.08-0.74, P = 0.013) and dyslipidaemia (OR 0.37, 95% CI 0.17-0.83, P = 0.015). However, these associations disappeared after correction for multiple tests. This study revealed that the coding variant rs1059491 is nominally associated with a decreased risk of obesity and dyslipidaemia in southern Chinese adults. The findings will be validated in larger studies including more detailed information on genetic background, lifestyle and weight change with age.
摘要：
在磺基转移酶（SULT）超家族中，SULT1家族的成员主要催化酚类化合物的磺化反应，参与II期代谢解毒过程，在内分泌稳态中起关键作用。据报道，SULT1A2基因中的编码变体rs1059491与儿童肥胖有关。本研究旨在探讨rs1059491与成人肥胖和心脏代谢异常风险的关系。这项病例对照研究包括226名正常体重，在台州进行健康体检的168名超重成年人和72名肥胖成年人，中国。通过在SULT1A2编码区的外显子7中的Sanger测序进行rs1059491的基因分型。卡方检验,单向方差分析,并应用逻辑回归模型。超重合并肥胖组和对照组rs1059491的次要等位基因频率分别为0.0292和0.0686。显性模子下TT基因型和GT+GG基因型之间体重和体重指数没有检测到差别，但G等位基因携带者的血清甘油三酯水平明显低于非G等位基因携带者（1.02（0.74-1.32）与1.35(0.83-2.13)mmol/L,P=0.011)。在调整性别和年龄后，rs1059491的GT+GG基因型与TT基因型相比，超重和肥胖的风险降低了54%(OR0.46，95%CI0.22-0.96，P=0.037)。高甘油三酯血症（OR0.25，95％CI0.08-0.74，P=0.013）和血脂异常（OR0.37，95％CI0.17-0.83，P=0.015）也观察到类似的结果。然而,这些关联在多次测试校正后消失.这项研究表明，编码变体rs1059491名义上与中国南方成年人肥胖和血脂异常的风险降低有关。这些发现将在更大的研究中得到验证，包括更详细的遗传背景信息，生活方式和体重随着年龄的增长而变化。
