PDF(Pubmed)
Abstract：
Photorhabdus insect-related toxins A and B (PirA and PirB) were first recognized as insecticidal toxins from Photorhabdus luminescens. However, subsequent studies showed that their homologs from Vibrio parahaemolyticus also play critical roles in the pathogenesis of acute hepatopancreatic necrosis disease (AHPND) in shrimps. Based on the structural features of the PirA/PirB toxins, it was suggested that they might function in the same way as a Bacillus thuringiensis Cry pore-forming toxin. However, unlike Cry toxins, studies on the PirA/PirB toxins are still scarce, and their cytotoxic mechanism remains to be clarified. In this review, based on our studies of V. parahaemolyticus PirAvp/PirBvp, we summarize the current understanding of the gene locations, expression control, activation, and cytotoxic mechanism of this type of toxin. Given the important role these toxins play in aquatic disease and their potential use in pest control applications, we also suggest further topics for research. We hope the information presented here will be helpful for future PirA/PirB studies.
摘要：
光纹相昆虫相关毒素A和B（PirA和PirB）首先被认为是发光光纹相的杀虫毒素。然而,随后的研究表明，它们来自副溶血性弧菌的同源物在虾急性肝胰腺坏死病（AHPND）的发病机理中也起着关键作用。根据PirA/PirB毒素的结构特征，有人认为，它们的功能可能与苏云金芽孢杆菌Cry成孔毒素相同。然而,不像哭泣毒素，关于PirA/PirB毒素的研究仍然很少，其细胞毒性机制仍有待阐明。在这次审查中,根据我们对副溶血性弧菌PirAvp/PirBvp的研究，我们总结了目前对基因位置的理解，表达式控件,激活,和这种毒素的细胞毒性机制。鉴于这些毒素在水生疾病中的重要作用及其在害虫控制应用中的潜在用途，我们还提出了进一步的研究主题。我们希望这里提供的信息将有助于未来的PirA/PirB研究。
