Abstract：
Atg18, Atg21 and Hsv2 are homologous β-propeller proteins binding to PI3P and PI(3,5)P2. Atg18 is thought to organize lipid transferring protein complexes at contact sites of the growing autophagosome (phagophore) with both the ER and the vacuole. Atg21 is restricted to the vacuole phagophore contact, where it organizes part of the Atg8-lipidation machinery. The role of Hsv2 is less understood, it partly affects micronucleophagy. Atg18 is further involved in regulation of PI(3,5)P2 synthesis. Recently, a novel Atg18-retromer complex and its role in vacuole homeostasis and membrane fission was uncovered.
摘要：
Atg18、Atg21和Hsv2是与PI3P和PI(3,5)P2结合的同源β-推进器蛋白。Atg18被认为在生长中的自噬体（吞噬团）与ER和液泡的接触部位组织脂质转移蛋白复合物。Atg21仅限于液泡吞噬体接触，它组织了Atg8脂化机械的一部分。对Hsv2的作用了解较少，它部分影响微核吞噬。Atg18进一步参与PI(3,5)P2合成的调节。最近,揭示了一种新型的Atg18-retromer复合物及其在液泡稳态和膜裂变中的作用。
