We searched a total of six databases in June 2022 and retrieved the relevant studies. The population included adult (18+) individuals who either had been diagnosed or were at risk for developing MS and also had exposure to ACEs. Our primary outcomes include the risks of MS development, age of MS onset, and MS relapse rate in patients who were exposed to different types of ACEs.
A total of 11 studies were included in our review. A study reported that among 300 women diagnosed with MS, 71 (24%) reported a history of childhood abuse; moreover, with further research, it was concluded that ACEs were associated with the development of MS. Abuse that occurred 2-3 times per week was associated with an 18.81-fold increased risk of having MS when compared to the unexposed sample. The relapse rate of MS was found to be substantially greater in severe cases of ACEs compared to individuals who did not report any ACEs.
Results support a significant association between ACEs and the development of MS; individuals with a positive history of ACEs develop MS symptoms earlier. Moreover, the severity of ACEs is also linked with increased relapse rates of MS.
方法:我们在2022年6月共检索了6个数据库,检索了相关研究。人群包括已被诊断或有患MS的风险并且也暴露于ACE的成年(18)个体。我们的主要结果包括MS发展的风险,MS发病年龄,暴露于不同类型ACE的患者的MS复发率。
结果:共有11项研究纳入我们的综述。一项研究报告说,在300名被诊断患有MS的女性中,71(24%)报告了儿童虐待史;此外,随着进一步的研究,结论是ACE与MS的发展有关。与未暴露样品相比,每周发生2-3次的滥用与MS风险增加18.81倍相关。与未报告任何ACE的个体相比,在严重的ACE病例中,MS的复发率明显更高。
结论:结果支持ACE与MS发展之间的显著关联;具有ACE阳性病史的个体较早发展MS症状。此外,ACEs的严重程度也与MS的复发率增加有关。