PDF(Pubmed)
Abstract：
Campylobacter is a major cause of food-borne gastrointestinal illnesses worldwide, predominantly affecting children under 5 years of age. This study examined potential associations of symptomatic (with diarrhea) and asymptomatic (without diarrhea) Campylobacter infections with child growth among children under 5 years of age in South Asia. The Global Enteric Multicenter Study was conducted from 2007 to 2011 with a case-control design. Children were followed for 60 days after enrollment. Stool culture was performed to isolate Campylobacter spp. Among the 22,567 enrolled children, 9,439 were symptomatic, with 786 (8.28%) testing positive for Campylobacter. Conversely, 13,128 asymptomatic healthy controls were included, with 1,057 (8.05%) testing positive for Campylobacter. Growth faltering was observed in the symptomatic group, particularly among children aged 0-11 months (-0.19 height-for-age z score [HAZ]; 95% CI: -0.36, -0.03; P = 0.018) and 24-59 months (-0.16 HAZ; 95% CI: -0.28, -0.04; P = 0.010). However, in the asymptomatic group, growth faltering was observed only in the 24- to 59-month age group, in terms of HAZ (-0.15 HAZ; 95% CI: -0.24, -0.05; P = 0.002) and weight-for-height z score (-0.16; 95% CI: -0.26, -0.06; P = 0.001). These findings underscore the importance of immediate and enhanced introduction of preventive modalities to reduce the burden of Campylobacter infections and reduce their long-term sequelae.
摘要：
弯曲杆菌是全球食源性胃肠道疾病的主要原因，主要影响5岁以下儿童。这项研究调查了南亚5岁以下儿童中，有症状（腹泻）和无症状（无腹泻）弯曲杆菌感染与儿童生长的潜在关联。全球肠内多中心研究于2007年至2011年进行，采用病例对照设计。儿童入组后随访60天。进行粪便培养以分离弯曲杆菌属。在22,567名入学儿童中，有9,439例出现症状,786例（8.28%）弯曲杆菌检测呈阳性。相反，包括13,128名无症状健康对照，1,057（8.05%）的弯曲杆菌检测呈阳性。在有症状的组中观察到生长步履蹒跚，特别是在0-11个月(-0.19身高年龄z评分[HAZ];95%CI:-0.36,-0.03;P=0.018)和24-59个月(-0.16HAZ;95%CI:-0.28,-0.04;P=0.010)的儿童中.然而,在无症状组中，仅在24至59月龄组中观察到生长步履蹒跚，HAZ(-0.15HAZ;95%CI:-0.24,-0.05;P=0.002)和身高体重z评分(-0.16;95%CI:-0.26,-0.06;P=0.001)。这些发现强调了立即和加强预防措施的重要性，以减轻弯曲杆菌感染的负担并减少其长期后遗症。
