PDF(Pubmed)
Abstract：
Hydatid cyst is a zoonotic infestation caused by Echinococcus granulosus, and it is known that some parasites found in humans cause cancer in humans or some may have a protective effect against cancer. Cancer is one of the most serious health problems of today and it has been shown in some studies that parasites such as Echinococcus granulosus can have an inhibitory effect. The aim of this study was determined as whether Echinococcus granulosus has an inhibitory effect on exocrine pancreatic cancer with the help of the azaserine-rat model used in different cancer studies. Material and Methods: During experimental process a total of 45 male Wistar rats used, 14-day-old male Wistar rats were divided into groups according to the experimental protocol, administered azaserine injection protocol or kept as a control group without azaserine injection. Animals are grouped as Group 1, Control Group (group not treated with Azaserine and not injected with protoscolex.) (E-A-) (n=7); Group 2, Group injected with (IP) Azaserine only (30mg/kg) (E-A+) (n=8);Group 3, Group injected (IP) with protoscolex suspension of 1 cc only (E+A-) (n=15);Group 4, Group injected both Azaserine (IP) and protoscolex suspension (IP) (E+A+) (n=15). Atypical Acinar Cell Foci (AACF) load in the exocrine pancreas of each rat was measured quantitatively with the help of a video image analyzer and the AACF load was calculated with the help of a mathematical model. Results: Findings showed that the Atypical Acinar Cell Foci (AACF) burden was statistically significantly lower in the Azaserine+ protoscolex (Azaserine-injected-protoscolex-implanted) rat group compared to the other groups, suggesting that Echinococcosis in the azaserine-rat model could inhibit the development of precursor foci of neoplastic changes in the exocrine pancreas. Conclusion: The most significant aspect of our study is that it contributes new insights into the controversy that Echinococcosis suppresses pancreatic cancer.
摘要：
包虫囊肿是由细粒棘球蚴引起的人畜共患，众所周知，在人类中发现的一些寄生虫会导致人类癌症，或者一些可能对癌症有保护作用。癌症是当今最严重的健康问题之一，一些研究表明，细粒棘球蚴等寄生虫具有抑制作用。这项研究的目的是确定在不同癌症研究中使用的azaserine大鼠模型的帮助下，细粒棘球蚴是否对外分泌胰腺癌具有抑制作用。材料和方法：在实验过程中，共使用45只雄性Wistar大鼠，根据实验方案将14天大的雄性Wistar大鼠分组，给予阿扎塞林注射方案或作为对照组不注射阿扎塞林。将动物分组为第1组,对照组(未用Azaserine处理且未注射原头节的组。）（E-A-）（n=7）；第2组，仅注射（IP）Azaserine（30mg/kg）（E-A）（n=8）；第3组，仅注射1cc（EA-）（n=15）的Protoscosousex悬浮液（IP）；第4组，既注射了Azaserine（IP）又注射了protoscosousou借助视频图像分析仪定量测量每只大鼠外分泌胰腺中的非典型腺泡细胞灶（AACF）负荷，并借助数学模型计算AACF负荷。结果：研究结果表明，与其他组相比，AzaserineProtoscosex（注射Azaserine-protoscosex-placed）大鼠组的非典型腺泡细胞灶（AACF）负荷在统计学上显着降低，提示阿扎司林大鼠模型中的棘球蚴病可以抑制外分泌胰腺肿瘤改变的前体病灶的发展。结论：我们研究的最重要方面是，它为棘球蚴病抑制胰腺癌的争议提供了新的见解。
