Abstract：
UNASSIGNED: Several observations have shown that patients with polycythemia have iron deficiency. Our objectives were to report the prevalence of iron deficiency and to evaluate the diagnostic performance of serum ferritin in polycythemia vera.
UNASSIGNED: This is a retrospective descriptive and analytical study carried out in the internal medicine department of the Henri Mondor Hospital, Aurillac, France. The study involved 114 patients with polycythemia, followed in the department from January 1, 2010 to December 31, 2021. To evaluate the diagnostic performance, the JAK2 mutation was considered as the gold standard of diagnosis.
UNASSIGNED: Thirty-three patients had polycythemia vera and 76 patients had secondary polycythemia. The mean age of the patients was 61.79 years (±15.44) with a sex ratio of 4.43. The overall prevalence of iron deficiency was 21.05%. The prevalence was 53% in polycythemia vera group and 1.32% in secondary polycythemia group. The risk of iron deficiency was high in polycythemia vera (OR = 115; 95% CI [14.4-918.2], p < 0.0001) and the sensitivity and specificity of serum ferritin were 52.63% and 100% respectively.
UNASSIGNED: Assessment of iron deficiency should be part of the initial evaluation of polycythemia. Iron deficiency had a high specificity during polycythemia vera.
UNASSIGNED: This is a retrospective descriptive and analytical study carried out in the internal medicine department of the Henri Mondor Hospital, Aurillac, France. The study involved 114 patients with polycythemia, followed in the department from January 1, 2010 to December 31, 2021. To evaluate the diagnostic performance, the JAK2 mutation was considered as the gold standard of diagnosis.
UNASSIGNED: Thirty-three patients had polycythemia vera and 76 patients had secondary polycythemia. The mean age of the patients was 61.79 years (±15.44) with a sex ratio of 4.43. The overall prevalence of iron deficiency was 21.05%. The prevalence was 53% in polycythemia vera group and 1.32% in secondary polycythemia group. The risk of iron deficiency was high in polycythemia vera (OR = 115; 95% CI [14.4-918.2], p < 0.0001) and the sensitivity and specificity of serum ferritin were 52.63% and 100% respectively.
UNASSIGNED: Assessment of iron deficiency should be part of the initial evaluation of polycythemia. Iron deficiency had a high specificity during polycythemia vera.
摘要：
■一些观察显示红细胞增多症患者缺铁。我们的目的是报告铁缺乏的患病率，并评估血清铁蛋白在真性红细胞增多症中的诊断性能。
■这是一项在HenriMondor医院内科进行的回顾性描述性和分析性研究，Aurillac,法国。这项研究涉及114名红细胞增多症患者，随后于2010年1月1日至2021年12月31日在该部门进行。要评估诊断性能，JAK2突变被认为是诊断的金标准.
■33例患者有真性红细胞增多症，76例患者有继发性红细胞增多症。患者的平均年龄为61.79岁（±15.44），性别比为4.43。铁缺乏的总患病率为21.05%。真性红细胞增多症组的患病率为53％，继发性红细胞增多症组的患病率为1.32％。真性红细胞增多症铁缺乏的风险较高(OR=115;95%CI[14.4-918.2],p<0.0001），血清铁蛋白的敏感性和特异性分别为52.63％和100％。
■缺铁性评估应该是红细胞增多症初步评估的一部分。铁缺乏在真性红细胞增多症中具有很高的特异性。
■这是一项在HenriMondor医院内科进行的回顾性描述性和分析性研究，Aurillac,法国。这项研究涉及114名红细胞增多症患者，随后于2010年1月1日至2021年12月31日在该部门进行。要评估诊断性能，JAK2突变被认为是诊断的金标准.
■33例患者有真性红细胞增多症，76例患者有继发性红细胞增多症。患者的平均年龄为61.79岁（±15.44），性别比为4.43。铁缺乏的总患病率为21.05%。真性红细胞增多症组的患病率为53％，继发性红细胞增多症组的患病率为1.32％。真性红细胞增多症铁缺乏的风险较高(OR=115;95%CI[14.4-918.2],p<0.0001），血清铁蛋白的敏感性和特异性分别为52.63％和100％。
■缺铁性评估应该是红细胞增多症初步评估的一部分。铁缺乏在真性红细胞增多症中具有很高的特异性。
