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Abstract：
Malignant tumors seriously endanger human health and life, and restrict economic development. Human leukocyte antigen (HLA) is the expression product of the human major histocompatibility complex, which, at present, is the most complex known polymorphic system. The polymorphism and expression of HLA molecules have been demonstrated to be associated with the occurrence and development of tumors. HLA molecules can regulate the proliferation of tumor cells and inhibit antitumor immunity. In the present review, the structure and function of HLA molecules, the polymorphism and expression of HLA in tumor tissue, the roles of HLA in tumor cells and tumor immunity, and the potential clinical application of HLA in tumor immunotherapy are summarized. The overall aim of the present review is to provide relevant information for the development of antitumor immunotherapies involving HLA in the clinic.
摘要：
恶性肿瘤严重危害人类健康和生命,制约经济发展。人类白细胞抗原（HLA）是人类主要组织相容性复合物的表达产物，which,目前,是已知最复杂的多态系统。HLA分子的多态性和表达已被证明与肿瘤的发生发展有关。HLA分子可以调节肿瘤细胞的增殖，抑制抗肿瘤免疫。在本次审查中，HLA分子的结构和功能，HLA在肿瘤组织中的多态性和表达，HLA在肿瘤细胞和肿瘤免疫中的作用，总结了HLA在肿瘤免疫治疗中的潜在临床应用。本综述的总体目标是为临床上涉及HLA的抗肿瘤免疫疗法的开发提供相关信息。
