PDF(Pubmed)
Abstract：
Lately, the global incidence of flavivirus infection has been increasing dramatically and presents formidable challenges for public health systems around the world. Most clinically significant flaviviruses are mosquito-borne, such as the four serotypes of dengue virus, Zika virus, West Nile virus, Japanese encephalitis virus and yellow fever virus. Until now, no effective antiflaviviral drugs are available to fight flaviviral infection; thus, a highly immunogenic vaccine would be the most effective weapon to control the diseases. In recent years, flavivirus vaccine research has made major breakthroughs with several vaccine candidates showing encouraging results in preclinical and clinical trials. This review summarizes the current advancement, safety, efficacy, advantages and disadvantages of vaccines against mosquito-borne flaviviruses posing significant threats to human health.
摘要：
最近,全球黄病毒感染的发病率急剧增加，并对世界各地的公共卫生系统提出了严峻的挑战。大多数临床上重要的黄病毒是蚊子传播的，例如登革热病毒的四种血清型，寨卡病毒,西尼罗河病毒,日本脑炎病毒和黄热病病毒。直到现在,没有有效的抗黄病毒药物可用于对抗黄病毒感染；因此，高免疫原性疫苗将是控制疾病的最有效武器。近年来,黄病毒疫苗研究取得了重大突破，一些候选疫苗在临床前和临床试验中显示出令人鼓舞的结果。这篇综述总结了目前的进展，安全,功效,对人类健康构成重大威胁的蚊媒黄病毒疫苗的优点和缺点。
