PDF(Pubmed)
Abstract：
Sarcoidosis is a non-necrotizing granulomatous inflammatory multisystemic disorder of unknown etiology. In children, as in adults, it can involve a few or all organ systems to a varying extent and degree, entailing multisystemic manifestations. Kidney involvement in pediatric-onset adult-type sarcoidosis is rare, with a wide range of renal manifestations, most of them related to calcium metabolism. Children with renal sarcoidosis tend to be more symptomatic than adults, although male patients have a higher prevalence. We present the case of a 10-year-old boy who presented with advanced renal failure with nephrocalcinosis and important hepatosplenomegaly. The diagnosis was established by histopathological examination, with consequent cortisone therapy and hemodialysis. This review emphasizes that sarcoidosis should be considered in the differential diagnosis of pediatric patients with acute kidney insufficiency or chronic kidney disease of an unknown etiology. As far as we know, this is the first study regarding extrapulmonary sarcoidosis in children from Romania.
摘要：
结节病是一种病因不明的非坏死性肉芽肿性炎症性多系统疾病。在儿童中，就像成年人一样，它可以在不同程度和程度上涉及几个或所有器官系统，涉及多系统表现。小儿起病的成人结节病的肾脏受累很少见，广泛的肾脏表现，其中大部分与钙代谢有关。儿童肾结节病往往比成人更有症状，虽然男性患者的患病率较高。我们介绍了一个10岁男孩的病例，该男孩患有晚期肾衰竭并伴有肾钙质沉着和重要的肝脾肿大。诊断是通过组织病理学检查确定的，随之而来的可的松治疗和血液透析。这篇综述强调，结节病在急性肾功能不全或病因不明的慢性肾脏疾病的儿科患者的鉴别诊断中应考虑。据我们所知,这是关于罗马尼亚儿童肺外结节病的第一项研究.
