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Abstract：
Antibiotic stewardship has been prioritized by governments and health care organizations in recent years as antibiotic resistance is markedly increasing. A tertiary hospital in Guangzhou, China was chosen as a study example to undertake an implementation and effectiveness evaluation of China\'s antibiotic stewardship to improve and promote antimicrobial stewardship nationwide. The general surgery department of the study hospital was utilized to examine surgical site infection, and samples from across the hospital were used to identify bloodstream infection. Data was analyzed using descriptive analysis, the Mann-Kendall trend test, logit model and panel data model, and t-tests. In terms of prophylactic and therapeutic antibiotic rational use, respectively, we evaluated implementation conditions, the correlation between implementation and corresponding disease progress, and the cost-effectiveness of China\'s antibiotic stewardship. For perioperative prophylactic antibiotic use, antibiotic stewardship was found to have been well-implemented, cost-effective, and reduced the incidence of surgical site infection. However, concerning therapeutic use and antibiotic-resistant bacterial infection prophylaxis, the complexity of influencing factors and the contradiction between stewardship implementation and clinical demand needs to be further evaluated.
摘要：
近年来，随着抗生素耐药性的显着增加，政府和医疗保健组织已将抗生素管理列为优先事项。广州市某三甲医院,以中国为例，对中国的抗生素管理进行了实施和有效性评估，以改善和促进全国的抗生素管理。研究医院的普外科用于检查手术部位感染，和来自整个医院的样本被用来识别血流感染。数据分析采用描述性分析，Mann-Kendall趋势测试,logit模型和面板数据模型，和t检验。在预防性和治疗性抗生素的合理使用方面，分别,我们评估了实施条件，实施与相应疾病进展之间的相关性，以及中国抗生素管理的成本效益。围手术期预防性使用抗生素，抗生素管理被发现得到了很好的实施，成本效益高,降低了手术部位感染的发生率。然而,关于治疗用途和抗生素耐药性细菌感染的预防，影响因素的复杂性以及管理实施与临床需求之间的矛盾有待进一步评估。
