PDF(Pubmed)
Abstract：
UNASSIGNED: Impaired left ventricular (LV) relaxation is indicative of grade I diastolic dysfunction, which is mainly assessed by late diastolic transmitral flow velocity (E/A ratio). Although the E/A ratio has important diagnostic and prognostic implications with cardiac outcomes, the causal link between abnormal E/A ratio and left ventricle remodeling (LV remodeling) remains unclear.
UNASSIGNED: A longitudinal analysis of 869 eligible women aged ≥45 years, who had received echocardiography scans as well as 5-year follow-up assessments between 2015 and 2020. Women with pre-existing cardiac abnormalities including grade II/III diastolic dysfunction as diagnosed by echocardiography, or structural heart disease were excluded. E/A abnormality was defined as baseline E/A ratio <0.8. The classification of LV remodeling was based on the measurements of left ventricular mass index (LVMI) and relative wall thickness (RWT). Logistic and linear regression models were used.
UNASSIGNED: Among the 869 women (60.71±10.01 years), 164 (18.9%) had developed LV remodeling after the 5-year follow-up. The proportion of women with E/A abnormality versus non-abnormality was also significantly different (27.13% vs 16.59%, P=0.007). Multivariable-adjusted regression models showed that E/A abnormality (OR: 4.14, 95%Cl:1.80-9.20, P=0.009) was significantly associated with higher risk of concentric hypertrophy (CH) after follow-up. No such association was found in either concentric remodeling (CR) or eccentric hypertrophy (EH). Higher baseline E/A ratio was correlated with lower ΔRWT during the 5-year follow-up (β=-0.006 m/s, 95% CI: -0.012 to -0.002, P=0.025), which was independent of demographics and biological factors.
UNASSIGNED: E/A abnormality is associated with a higher risk of CH. Higher baseline E/A ratio may be associated with decreased relative changes in RWT.
UNASSIGNED: A longitudinal analysis of 869 eligible women aged ≥45 years, who had received echocardiography scans as well as 5-year follow-up assessments between 2015 and 2020. Women with pre-existing cardiac abnormalities including grade II/III diastolic dysfunction as diagnosed by echocardiography, or structural heart disease were excluded. E/A abnormality was defined as baseline E/A ratio <0.8. The classification of LV remodeling was based on the measurements of left ventricular mass index (LVMI) and relative wall thickness (RWT). Logistic and linear regression models were used.
UNASSIGNED: Among the 869 women (60.71±10.01 years), 164 (18.9%) had developed LV remodeling after the 5-year follow-up. The proportion of women with E/A abnormality versus non-abnormality was also significantly different (27.13% vs 16.59%, P=0.007). Multivariable-adjusted regression models showed that E/A abnormality (OR: 4.14, 95%Cl:1.80-9.20, P=0.009) was significantly associated with higher risk of concentric hypertrophy (CH) after follow-up. No such association was found in either concentric remodeling (CR) or eccentric hypertrophy (EH). Higher baseline E/A ratio was correlated with lower ΔRWT during the 5-year follow-up (β=-0.006 m/s, 95% CI: -0.012 to -0.002, P=0.025), which was independent of demographics and biological factors.
UNASSIGNED: E/A abnormality is associated with a higher risk of CH. Higher baseline E/A ratio may be associated with decreased relative changes in RWT.
摘要：
■左心室（LV）舒张功能受损是I级舒张功能障碍的指示，主要通过舒张末期血流速度（E/A比）进行评估。尽管E/A比值对心脏结果具有重要的诊断和预后意义，E/A比值异常与左心室重构(LV重构)之间的因果关系尚不清楚.
■对869名年龄≥45岁的合格女性进行纵向分析，在2015年至2020年间接受了超声心动图扫描以及5年随访评估的患者.先前存在心脏异常的女性，包括通过超声心动图诊断的II/III级舒张功能障碍，或结构性心脏病被排除。E/A异常定义为基线E/A比<0.8。左心室重塑的分类基于左心室质量指数（LVMI）和相对壁厚（RWT）的测量。使用Logistic和线性回归模型。
■在869名女性（60.71±10.01岁）中，164例（18.9%）在5年随访后发生了LV重塑。E/A异常与非异常的女性比例也有显著差异(27.13%vs16.59%,P=0.007)。多变量校正回归模型显示,E/A异常(OR:4.14,95%Cl:1.80~9.20,P=0.009)与随访后向心性肥大(CH)的风险显著相关。在同心重塑（CR）或偏心肥大（EH）中均未发现这种关联。在5年随访期间，较高的基线E/A比与较低的ΔRWT相关(β=-0.006m/s，95%CI：-0.012至-0.002，P=0.025），这与人口统计学和生物学因素无关。
■E/A异常与更高的CH风险相关。较高的基线E/A比可能与RWT的相对变化减少相关。
■对869名年龄≥45岁的合格女性进行纵向分析，在2015年至2020年间接受了超声心动图扫描以及5年随访评估的患者.先前存在心脏异常的女性，包括通过超声心动图诊断的II/III级舒张功能障碍，或结构性心脏病被排除。E/A异常定义为基线E/A比<0.8。左心室重塑的分类基于左心室质量指数（LVMI）和相对壁厚（RWT）的测量。使用Logistic和线性回归模型。
■在869名女性（60.71±10.01岁）中，164例（18.9%）在5年随访后发生了LV重塑。E/A异常与非异常的女性比例也有显著差异(27.13%vs16.59%,P=0.007)。多变量校正回归模型显示,E/A异常(OR:4.14,95%Cl:1.80~9.20,P=0.009)与随访后向心性肥大(CH)的风险显著相关。在同心重塑（CR）或偏心肥大（EH）中均未发现这种关联。在5年随访期间，较高的基线E/A比与较低的ΔRWT相关(β=-0.006m/s，95%CI：-0.012至-0.002，P=0.025），这与人口统计学和生物学因素无关。
■E/A异常与更高的CH风险相关。较高的基线E/A比可能与RWT的相对变化减少相关。
