PDF(Pubmed)
Abstract：
A patient with schizophrenia who was treated with chlorpromazine developed lupus anticoagulant (LA) and antiphospholipid syndrome (APS). On protein electrophoresis, a monoclonal immunoglobulin A peak was seen in this patient, defining a condition of monoclonal gammopathy of undetermined significance. Additionally, β-thalassemia was diagnosed with the CD41-42 genotype. This condition is extremely rare, particularly in patients with schizophrenia and APS. We present a case of a patient with schizophrenia and secondary APS who had a positive LA, a significantly prolonged activated partial thromboplastin time, endogenous coagulation factor deficiency and inhibitor, no bleeding, and an unexpected finding of β-thalassemia and monoclonal IgA. Following that, a literature review on the disorders was presented.
摘要：
一名接受氯丙嗪治疗的精神分裂症患者出现了狼疮抗凝药（LA）和抗磷脂综合征（APS）。在蛋白质电泳上，该患者出现单克隆免疫球蛋白A峰,定义一种意义不明的单克隆丙种球蛋白病。此外,β-地中海贫血被诊断为CD41-42基因型。这种情况极为罕见,特别是精神分裂症和APS患者。我们介绍了一例精神分裂症和继发性APS患者，其LA阳性，显著延长的活化部分凝血活酶时间，内源性凝血因子缺乏和抑制剂，没有出血,以及β-地中海贫血和单克隆IgA的意外发现。在此之后,对这些疾病进行了文献综述.
