PDF(Pubmed)
Abstract：
Gastrointestinal stromal tumors (GISTs) are one of the most common, potentially malignant, subepithelial lesions identified in the gastrointestinal tract. Hypothesized to derive from the interstitial cells of Cajal (ICC), GISTs commonly demonstrate gain of function mutations in proto-oncogenic receptor tyrosine kinase CD117 (KIT). Depending on mitotic activity and tumor size characteristics, GISTs may transform from benign to malignant neoplasms. Increasing evidence suggests that early identification of a GIST is paramount for optimal prognostic outcomes. We present a rare case of a GIST located in the uncinate pancreas identified via endoscopic ultrasound (EUS) and diagnosed with an EUS-guided fine needle aspiration (EUS-FNA) biopsy.
摘要：
胃肠道间质瘤(GIST)是最常见的,潜在的恶性,在胃肠道中发现的上皮下病变。假设来自Cajal（ICC）的间质细胞，GIST通常显示原癌基因受体酪氨酸激酶CD117（KIT）的功能获得突变。根据有丝分裂活性和肿瘤大小特征，GIST可从良性肿瘤转变为恶性肿瘤。越来越多的证据表明，早期识别GIST对于最佳预后结果至关重要。我们介绍了一例罕见的GIST病例，该病例位于通过内窥镜超声（EUS）鉴定的钩部胰腺中，并通过EUS引导的细针穿刺（EUS-FNA）活检诊断。
