Abstract：
BACKGROUND: Leuconostoc spp. are facultatively anaerobic Gram-positive cocci involved in cases of hospital-acquired bacteremia, mainly in immunocompromised hosts. The available data is scarce due to its uncommon presentation.
METHODS: We describe all the episodes of Leuconostoc spp. bacteremia in a third level hospital in a 13-year period (2008-2021).
RESULTS: Four cases of clinically relevant bacteremia were detected. All cases were categorized as catheter-related. The following risk factors were found: previous glycopeptide therapy (75%), use of parenteral nutrition (100%) and cancer (75%). All isolates showed susceptibility to beta-lactams. Catheter removal was performed and wide spectrum antimicrobials were administered, with clinical response in all cases except one.
CONCLUSIONS: Apart from cancer and glycopeptide exposure, disruption of skin barrier and gastrointestinal conditions were identified as risk factors, as it was concordantly underlined in other case series. Susceptibility to beta-lactams is usually maintained. Catheter removal and administration of an active antibacterial therapy seem to be the best approach for Leuconostoc spp. catheter-related bacteremia.
METHODS: We describe all the episodes of Leuconostoc spp. bacteremia in a third level hospital in a 13-year period (2008-2021).
RESULTS: Four cases of clinically relevant bacteremia were detected. All cases were categorized as catheter-related. The following risk factors were found: previous glycopeptide therapy (75%), use of parenteral nutrition (100%) and cancer (75%). All isolates showed susceptibility to beta-lactams. Catheter removal was performed and wide spectrum antimicrobials were administered, with clinical response in all cases except one.
CONCLUSIONS: Apart from cancer and glycopeptide exposure, disruption of skin barrier and gastrointestinal conditions were identified as risk factors, as it was concordantly underlined in other case series. Susceptibility to beta-lactams is usually maintained. Catheter removal and administration of an active antibacterial therapy seem to be the best approach for Leuconostoc spp. catheter-related bacteremia.
摘要：
背景：明串珠菌属。是医院获得性菌血症病例中涉及的兼性厌氧革兰氏阳性球菌，主要在免疫受损的宿主中。由于其不常见的呈现方式，可用数据很少。
方法：我们描述了明串珠菌属的所有发作。三级医院13年菌血症（2008-2021年）。
结果：发现4例临床相关菌血症。所有病例均被归类为导管相关。发现以下危险因素：以前的糖肽治疗（75％），使用肠外营养（100％）和癌症（75％）。所有分离株都显示出对β-内酰胺的敏感性。进行导管拔除并施用广谱抗微生物剂,除一例外，所有病例均有临床反应。
结论：除了癌症和糖肽暴露，皮肤屏障破坏和胃肠道疾病被确定为危险因素，正如在其他案例系列中一致强调的那样。通常维持对β-内酰胺的易感性。拔除导管和给予积极的抗菌治疗似乎是明串珠菌属的最佳方法。导管相关性菌血症.
方法：我们描述了明串珠菌属的所有发作。三级医院13年菌血症（2008-2021年）。
结果：发现4例临床相关菌血症。所有病例均被归类为导管相关。发现以下危险因素：以前的糖肽治疗（75％），使用肠外营养（100％）和癌症（75％）。所有分离株都显示出对β-内酰胺的敏感性。进行导管拔除并施用广谱抗微生物剂,除一例外，所有病例均有临床反应。
结论：除了癌症和糖肽暴露，皮肤屏障破坏和胃肠道疾病被确定为危险因素，正如在其他案例系列中一致强调的那样。通常维持对β-内酰胺的易感性。拔除导管和给予积极的抗菌治疗似乎是明串珠菌属的最佳方法。导管相关性菌血症.
