Abstract：
To assess the efficacy and safety of a 1927-nm fractional thulium fiber laser treatment for Becker\'s nevus.
A retrospective analysis of patients with Becker\'s nevus who were treated with a 1927-nm fractional thulium fiber laser was conducted. Grading for lightening was set quarterly by physician global assessment of the pre- and postphotographs (I: <25%; II: 25%-50%; III: 51%-75%; and IV: >75% for marked lightening). Grading validation was exercised using intra- and interobserver agreement analysis among 10 dermatologists to determine the percent of agreement and the intraclass correlation coefficient. Grades I and II were classified as treatment failure.
A total of 21 patients were recruited for analysis. The average number of treatment sessions was 2.1 per patient. A total of 13 patients achieved successful outcomes (grades III and IV) while 8 patients experienced treatment failure (grades I and II). Partial recurrence and transient hypopigmentation on adjacent skin were the main adverse effects. Only one patient reported worsening of the nevus. Overall agreement among the raters for the outcomes was graded from \"very good\" to \"excellent,\" and the intraclass correlation coefficient, kappa, was 0.8.
A 1927-nm fractional thulium fiber laser may be effective to ameliorate the pigment of Becker\'s nevus and achieve acceptable cosmetic outcomes. However, further studies are required in this area to improve and optimize the results.
A retrospective analysis of patients with Becker\'s nevus who were treated with a 1927-nm fractional thulium fiber laser was conducted. Grading for lightening was set quarterly by physician global assessment of the pre- and postphotographs (I: <25%; II: 25%-50%; III: 51%-75%; and IV: >75% for marked lightening). Grading validation was exercised using intra- and interobserver agreement analysis among 10 dermatologists to determine the percent of agreement and the intraclass correlation coefficient. Grades I and II were classified as treatment failure.
A total of 21 patients were recruited for analysis. The average number of treatment sessions was 2.1 per patient. A total of 13 patients achieved successful outcomes (grades III and IV) while 8 patients experienced treatment failure (grades I and II). Partial recurrence and transient hypopigmentation on adjacent skin were the main adverse effects. Only one patient reported worsening of the nevus. Overall agreement among the raters for the outcomes was graded from \"very good\" to \"excellent,\" and the intraclass correlation coefficient, kappa, was 0.8.
A 1927-nm fractional thulium fiber laser may be effective to ameliorate the pigment of Becker\'s nevus and achieve acceptable cosmetic outcomes. However, further studies are required in this area to improve and optimize the results.
摘要：
目的：评估1927-nm激光激光分割治疗Becker痣的疗效和安全性。
方法：对采用1927nm激光点阵的Becker痣患者进行回顾性分析。根据医生对前后照片的全球评估，每季度确定一次减轻等级（I：<25％；II：25％-50％；III：51％-75％；IV：>75％用于明显的减轻）。使用10位皮肤科医生之间的观察者内部和观察者之间的一致性分析进行分级验证，以确定一致性百分比和组内相关系数。I级和II级被分类为治疗失败。
结果：共招募21名患者进行分析。平均每个患者的治疗次数为2.1次。共有13名患者获得了成功的结果（III级和IV级），而8名患者经历了治疗失败（I级和II级）。部分复发和邻近皮肤短暂色素沉着不足是主要不良反应。只有一名患者报告痣恶化。评估者对结果的总体一致性从“非常好”到“优秀”，“和组内相关系数，kappa,是0.8
结论：1927nm激光激光可以有效改善Becker痣的色素并达到可接受的美容效果。然而,需要在这方面进行进一步的研究，以改进和优化结果。
方法：对采用1927nm激光点阵的Becker痣患者进行回顾性分析。根据医生对前后照片的全球评估，每季度确定一次减轻等级（I：<25％；II：25％-50％；III：51％-75％；IV：>75％用于明显的减轻）。使用10位皮肤科医生之间的观察者内部和观察者之间的一致性分析进行分级验证，以确定一致性百分比和组内相关系数。I级和II级被分类为治疗失败。
结果：共招募21名患者进行分析。平均每个患者的治疗次数为2.1次。共有13名患者获得了成功的结果（III级和IV级），而8名患者经历了治疗失败（I级和II级）。部分复发和邻近皮肤短暂色素沉着不足是主要不良反应。只有一名患者报告痣恶化。评估者对结果的总体一致性从“非常好”到“优秀”，“和组内相关系数，kappa,是0.8
结论：1927nm激光激光可以有效改善Becker痣的色素并达到可接受的美容效果。然而,需要在这方面进行进一步的研究，以改进和优化结果。
