PDF(Pubmed)
Abstract：
UNASSIGNED: Olanzapine toxicity is reported to be a rare but specific phenomenon characterized by rapid fluctuations between somnolence and agitation, which has been referred to as \"agitation despite sedation.\" A similar phenomenon is observed as an adverse reaction of the long-acting injectable olanzapine formulation, which has been referred to as \"delirium/sedation syndrome.\"
UNASSIGNED: This case report describes a 48-year-old man diagnosed with schizophrenia who experienced rapid fluctuations between somnolence and agitation during a cross-titration of olanzapine to clozapine. The patient had normal serum levels of both medications and the symptoms resolved with the discontinuation of olanzapine.
UNASSIGNED: Rapid fluctuations in mental status between somnolence and agitation are not clearly described among other antipsychotics, and it is possible that this phenomenon may be specific to olanzapine. The findings of this case report suggested that this phenomenon was likely the result of the oversaturation of (H1) and (M1) receptors.
UNASSIGNED: This case report describes a 48-year-old man diagnosed with schizophrenia who experienced rapid fluctuations between somnolence and agitation during a cross-titration of olanzapine to clozapine. The patient had normal serum levels of both medications and the symptoms resolved with the discontinuation of olanzapine.
UNASSIGNED: Rapid fluctuations in mental status between somnolence and agitation are not clearly described among other antipsychotics, and it is possible that this phenomenon may be specific to olanzapine. The findings of this case report suggested that this phenomenon was likely the result of the oversaturation of (H1) and (M1) receptors.
摘要：
■据报道，奥氮平毒性是一种罕见但特殊的现象，其特征是嗜睡和躁动之间的快速波动，尽管镇静，这也被称为“搅动”。“观察到类似的现象是长效可注射奥氮平制剂的不良反应，这被称为“谵妄/镇静综合征”。\"
■本病例报告描述了一名48岁的精神分裂症患者，在奥氮平与氯氮平的交叉滴定过程中，他经历了嗜睡和躁动之间的快速波动。患者两种药物的血清水平均正常，停用奥氮平后症状缓解。
■在其他抗精神病药物中，没有清楚地描述嗜睡和躁动之间精神状态的快速波动，这种现象可能是奥氮平特有的。该病例报告的结果表明，这种现象可能是（H1）和（M1）受体过饱和的结果。
■本病例报告描述了一名48岁的精神分裂症患者，在奥氮平与氯氮平的交叉滴定过程中，他经历了嗜睡和躁动之间的快速波动。患者两种药物的血清水平均正常，停用奥氮平后症状缓解。
■在其他抗精神病药物中，没有清楚地描述嗜睡和躁动之间精神状态的快速波动，这种现象可能是奥氮平特有的。该病例报告的结果表明，这种现象可能是（H1）和（M1）受体过饱和的结果。
