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Abstract：
BACKGROUND: Intraoral minor salivary gland tumors are relatively rare lesions with histological subtypes not commonly found in major salivary glands. This study aimed to retrospectively evaluate the clinicopathologic features of intraoral minor salivary gland tumors from the Tokyo Dental College Hospital, Japan, and compare them with findings from other epidemiological studies.
METHODS: We conducted a retrospective clinicopathologic evaluation of 432 cases of intraoral minor salivary gland tumors [161 male (37.3%) and 271 female (62.7%) patients; mean age: 52.5 and 48.6 years for males and females, respectively; age at diagnosis: 7-87 (mean: 50.1) years] from the Tokyo Dental College Hospital between 1975 and 2022, including 283 benign tumors (65.5%) and 149 malignant tumors (34.5%).
RESULTS: The most common benign tumor was pleomorphic adenoma (n = 239), whereas mucoepidermoid carcinoma was the most common malignant tumor (n = 74). The mean age of patients with benign and malignant tumors was 48.4 and 53.2 years, respectively, with patients with malignant tumors being significantly older (P = 0.0042). The mean age of patients with malignant tumors was significantly higher in males (56.7 years) than in females (50.9 years) (P = 0.0376), although the mean age of patients with benign tumors did not differ by sex. Tumors were commonly located in the palate [250 cases (57.9%)]. Benign tumors were more frequent in the palate, upper lip, and buccal mucosa, whereas malignant tumors were more frequent in the palate, floor of the mouth, buccal mucosa, and retromolar area.
CONCLUSIONS: Understanding the features of intraoral minor salivary gland tumors is useful for diagnosis. Our study provides important epidemiological data (patient differences in age at occurrence, sex, and site of origin) that will inform clinicians and researchers.
METHODS: We conducted a retrospective clinicopathologic evaluation of 432 cases of intraoral minor salivary gland tumors [161 male (37.3%) and 271 female (62.7%) patients; mean age: 52.5 and 48.6 years for males and females, respectively; age at diagnosis: 7-87 (mean: 50.1) years] from the Tokyo Dental College Hospital between 1975 and 2022, including 283 benign tumors (65.5%) and 149 malignant tumors (34.5%).
RESULTS: The most common benign tumor was pleomorphic adenoma (n = 239), whereas mucoepidermoid carcinoma was the most common malignant tumor (n = 74). The mean age of patients with benign and malignant tumors was 48.4 and 53.2 years, respectively, with patients with malignant tumors being significantly older (P = 0.0042). The mean age of patients with malignant tumors was significantly higher in males (56.7 years) than in females (50.9 years) (P = 0.0376), although the mean age of patients with benign tumors did not differ by sex. Tumors were commonly located in the palate [250 cases (57.9%)]. Benign tumors were more frequent in the palate, upper lip, and buccal mucosa, whereas malignant tumors were more frequent in the palate, floor of the mouth, buccal mucosa, and retromolar area.
CONCLUSIONS: Understanding the features of intraoral minor salivary gland tumors is useful for diagnosis. Our study provides important epidemiological data (patient differences in age at occurrence, sex, and site of origin) that will inform clinicians and researchers.
摘要：
背景：口腔内小涎腺肿瘤是相对罕见的病变，组织学亚型在大涎腺中不常见。本研究旨在回顾性评估东京牙科医院口腔内小唾液腺肿瘤的临床病理特征，Japan,并将它们与其他流行病学研究的结果进行比较。
方法：我们对432例口内小唾液腺肿瘤进行了回顾性临床病理评估[161例男性（37.3%）和271例女性（62.7%）；男女平均年龄：52.5岁和48.6岁，分别;诊断年龄：7-87（平均：50.1）岁]1975年至2022年之间，来自东京牙科学院医院，包括283个良性肿瘤（65.5％）和149个恶性肿瘤（34.5％）。
结果：最常见的良性肿瘤是多形性腺瘤（n=239），而粘液表皮样癌是最常见的恶性肿瘤（n=74）。良性和恶性肿瘤患者的平均年龄分别为48.4和53.2岁，分别,恶性肿瘤患者明显年龄较大（P=0.0042）。恶性肿瘤患者的平均年龄男性(56.7岁)明显高于女性(50.9岁)(P=0.0376),尽管良性肿瘤患者的平均年龄没有性别差异。肿瘤通常位于腭[250例（57.9％）]。良性肿瘤在腭中更常见，上唇,和颊粘膜，而恶性肿瘤在腭中更常见，嘴巴的地板，颊粘膜，和磨牙后区域。
结论：了解口腔内小唾液腺肿瘤的特征对诊断很有用。我们的研究提供了重要的流行病学数据(患者在发生时的年龄差异，性别,和产地)，这将告知临床医生和研究人员。
方法：我们对432例口内小唾液腺肿瘤进行了回顾性临床病理评估[161例男性（37.3%）和271例女性（62.7%）；男女平均年龄：52.5岁和48.6岁，分别;诊断年龄：7-87（平均：50.1）岁]1975年至2022年之间，来自东京牙科学院医院，包括283个良性肿瘤（65.5％）和149个恶性肿瘤（34.5％）。
结果：最常见的良性肿瘤是多形性腺瘤（n=239），而粘液表皮样癌是最常见的恶性肿瘤（n=74）。良性和恶性肿瘤患者的平均年龄分别为48.4和53.2岁，分别,恶性肿瘤患者明显年龄较大（P=0.0042）。恶性肿瘤患者的平均年龄男性(56.7岁)明显高于女性(50.9岁)(P=0.0376),尽管良性肿瘤患者的平均年龄没有性别差异。肿瘤通常位于腭[250例（57.9％）]。良性肿瘤在腭中更常见，上唇,和颊粘膜，而恶性肿瘤在腭中更常见，嘴巴的地板，颊粘膜，和磨牙后区域。
结论：了解口腔内小唾液腺肿瘤的特征对诊断很有用。我们的研究提供了重要的流行病学数据(患者在发生时的年龄差异，性别,和产地)，这将告知临床医生和研究人员。
