Abstract：
To test the changes of meibomian gland (MG) morphology using an artificial intelligence (AI) analytic system in asymptomatic children wearing overnight orthokeratology (OOK) and soft contact lens (SCL).
A retrospective study was conducted including 89 participants treated with OOK and 70 participants with SCL. Tear meniscus height (TMH), noninvasive tear breakup time (NIBUT), and meibography were obtained using Keratograph 5 M. MG tortuosity, height, width, density, and vagueness value were measured using an artificial intelligence (AI) analytic system.
In an average of 20.80 ± 10.83 months follow-up, MG width of the upper eyelid significantly increased and MG vagueness value significantly decreased after OOK and SCL treatment (all P < 0.05). MG tortuosity of the upper eyelid significantly increased after OOK treatment (P < 0.05). TMH and NIBUT did not differ significantly pre- and post- OOK and SCL treatment (all P > 0.05). The results from the GEE model demonstrated that OOK treatment positively affected MG tortuosity of both upper and lower eyelids (P < 0.001; P = 0.041, respectively) and MG width of the upper eyelid (P = 0.038), while it negatively affected MG density of the upper eyelid (P = 0.036) and MG vagueness value of both upper and lower eyelids (P < 0.001; P < 0.001, respectively). SCL treatment positively affected MG width of both upper and lower eyelids (P < 0.001; P = 0.049, respectively) as well as MG height of the lower eyelid (P = 0.009) and tortuosity of the upper eyelid, (P = 0.034) while it negatively affected MG vagueness value of both upper and lower eyelids (P < 0.001; P < 0.001, respectively). However, no significant relationship was found between the treatment duration and TMH, NIBUT, MG morphological parameters in OOK group. SCL treatment duration negatively affected MG height of the lower eyelid (P = 0.002).
OOK and SCL treatment in asymptomatic children can influence MG morphology. The AI analytic system may be an effective method to facilitate the quantitative detection of MG morphological changes.
A retrospective study was conducted including 89 participants treated with OOK and 70 participants with SCL. Tear meniscus height (TMH), noninvasive tear breakup time (NIBUT), and meibography were obtained using Keratograph 5 M. MG tortuosity, height, width, density, and vagueness value were measured using an artificial intelligence (AI) analytic system.
In an average of 20.80 ± 10.83 months follow-up, MG width of the upper eyelid significantly increased and MG vagueness value significantly decreased after OOK and SCL treatment (all P < 0.05). MG tortuosity of the upper eyelid significantly increased after OOK treatment (P < 0.05). TMH and NIBUT did not differ significantly pre- and post- OOK and SCL treatment (all P > 0.05). The results from the GEE model demonstrated that OOK treatment positively affected MG tortuosity of both upper and lower eyelids (P < 0.001; P = 0.041, respectively) and MG width of the upper eyelid (P = 0.038), while it negatively affected MG density of the upper eyelid (P = 0.036) and MG vagueness value of both upper and lower eyelids (P < 0.001; P < 0.001, respectively). SCL treatment positively affected MG width of both upper and lower eyelids (P < 0.001; P = 0.049, respectively) as well as MG height of the lower eyelid (P = 0.009) and tortuosity of the upper eyelid, (P = 0.034) while it negatively affected MG vagueness value of both upper and lower eyelids (P < 0.001; P < 0.001, respectively). However, no significant relationship was found between the treatment duration and TMH, NIBUT, MG morphological parameters in OOK group. SCL treatment duration negatively affected MG height of the lower eyelid (P = 0.002).
OOK and SCL treatment in asymptomatic children can influence MG morphology. The AI analytic system may be an effective method to facilitate the quantitative detection of MG morphological changes.
摘要：
目的：使用人工智能（AI）分析系统测试无症状儿童夜间角膜塑形镜（OOK）和软性隐形眼镜（SCL）的睑板腺（MG）形态的变化。
方法：进行了一项回顾性研究，包括89名接受OOK治疗的参与者和70名接受SCL治疗的参与者。撕裂弯月面高度(TMH),非侵入性泪液破裂时间（NIBUT），并且使用角膜描记术5M.MG弯曲，高度,宽度,密度,和模糊值是使用人工智能(AI)分析系统测量的。
结果：在平均20.80±10.83个月的随访中，OOK和SCL治疗后，上眼睑MG宽度显着增加，MG模糊值显着降低（均P<0.05）。OOK治疗后，MG上睑弯曲度明显增加（P<0.05）。在OOK和SCL治疗前后，TMH和NIBUT没有显着差异（均P>0.05）。GEE模型的结果表明，OOK治疗对上下眼睑的MG弯曲度（分别为P<0.001；P=0.041）和上眼睑的MG宽度（P=0.038）均有积极影响。同时对上眼睑的MG密度（P=0.036）和上下眼睑的MG模糊值（分别为P<0.001；P<0.001）产生负面影响。SCL治疗对上下眼睑的MG宽度（分别为P<0.001；P=0.049）以及下眼睑的MG高度（P=0.009）和上眼睑的弯曲度都有积极影响，（P=0.034），而对上下眼睑的MG模糊值产生负面影响（分别为P<0.001；P<0.001）。然而,治疗时间和TMH之间没有发现显著的关系，NIBUT,OOK组MG形态参数。SCL治疗持续时间对下眼睑的MG高度有负面影响（P=0.002）。
结论：OOK和SCL治疗无症状儿童可影响MG形态。AI分析系统可能是一种有助于定量检测MG形态变化的有效方法。
方法：进行了一项回顾性研究，包括89名接受OOK治疗的参与者和70名接受SCL治疗的参与者。撕裂弯月面高度(TMH),非侵入性泪液破裂时间（NIBUT），并且使用角膜描记术5M.MG弯曲，高度,宽度,密度,和模糊值是使用人工智能(AI)分析系统测量的。
结果：在平均20.80±10.83个月的随访中，OOK和SCL治疗后，上眼睑MG宽度显着增加，MG模糊值显着降低（均P<0.05）。OOK治疗后，MG上睑弯曲度明显增加（P<0.05）。在OOK和SCL治疗前后，TMH和NIBUT没有显着差异（均P>0.05）。GEE模型的结果表明，OOK治疗对上下眼睑的MG弯曲度（分别为P<0.001；P=0.041）和上眼睑的MG宽度（P=0.038）均有积极影响。同时对上眼睑的MG密度（P=0.036）和上下眼睑的MG模糊值（分别为P<0.001；P<0.001）产生负面影响。SCL治疗对上下眼睑的MG宽度（分别为P<0.001；P=0.049）以及下眼睑的MG高度（P=0.009）和上眼睑的弯曲度都有积极影响，（P=0.034），而对上下眼睑的MG模糊值产生负面影响（分别为P<0.001；P<0.001）。然而,治疗时间和TMH之间没有发现显著的关系，NIBUT,OOK组MG形态参数。SCL治疗持续时间对下眼睑的MG高度有负面影响（P=0.002）。
结论：OOK和SCL治疗无症状儿童可影响MG形态。AI分析系统可能是一种有助于定量检测MG形态变化的有效方法。
