Abstract：
The pyrin inflammasome detects bacterial toxins and effectors that inhibit RhoA GTPases and triggers inflammatory cytokine release and a fast cell death termed pyroptosis. In addition, various endogenous molecules, drugs, synthetic molecules, or mutations can trigger pyrin inflammasome activation. The pyrin protein differs between humans and mice, and the repertoire of pyrin activators is also species-specific. Here, we present the various pyrin inflammasome activators, inhibitors, the kinetics of pyrin activation in response to the various activators, and their species specificity. In addition, we present different methods to monitor pyrin-mediated pyroptosis.
摘要：
pyrin炎性体检测抑制RhoAGTP酶的细菌毒素和效应物，并触发炎性细胞因子释放和称为焦亡的快速细胞死亡。此外,各种内源性分子，毒品,合成分子，或突变可以触发pyrin炎性体激活。pyrin蛋白在人类和小鼠之间不同，并且pyrin激活剂的库也是物种特异性的。这里,我们介绍了各种pyrin炎性体激活剂，抑制剂，响应于各种激活剂的pyrin激活动力学，和它们的物种特异性。此外,我们提出了不同的方法来监测pyrin介导的焦亡。
