Abstract：
Melanoma and benign histiocytic proliferations can sometimes show considerable clinical and histopathologic overlap. Recently, cases of melanomas resembling xanthogranuloma and Rosai-Dorfman disease have been reported, and herein we report a case of melanoma closely mimicking reticulohistiocytoma. An 84-year-old man presented with a 1 cm purple-red nodule on his arm concerning for squamous cell carcinoma. While the biopsy findings resembled reticulohistiocytoma, the clinical context and regression changes at the lesion perimeter raised stronger concern for melanoma, which was confirmed with immunohistochemistry. We review prior rare reports of melanomas resembling non-Langerhans cell histiocytic proliferations and summarize helpful clinical and histopathologic clues to avoid a diagnostic pitfall when confronted with this unusual quandary.
摘要：
黑色素瘤和良性组织细胞增生有时会显示出相当大的临床和组织病理学重叠。最近,已经报道了类似黄色肉芽肿和Rosai-Dorfman病的黑色素瘤病例，在此，我们报告了一例与网状组织细胞瘤相似的黑色素瘤。一名84岁的男子手臂上有一个1厘米的紫红色结节，涉及鳞状细胞癌。虽然活检结果类似于网状组织细胞瘤，病变周边的临床背景和回归变化引起了对黑色素瘤的更强烈关注，免疫组织化学证实了这一点。我们回顾了先前罕见的类似于非朗格汉斯细胞组织细胞增殖的黑色素瘤的报道，并总结了有用的临床和组织病理学线索，以避免在遇到这种不寻常的困境时出现诊断陷阱。
