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Abstract：
UNASSIGNED: Inflammation and thrombosis are involved in the development of stroke-associated pneumonia (SAP). Our aim was to evaluate the predictive value of a novel, simplified, thrombo-inflammatory prognostic score (TIPS) that combines both inflammatory and thrombus biomarkers in the early phase of ischemic stroke (IS).
UNASSIGNED: The study population consisted of 897 patients with a first diagnosis of IS admitted to the emergency department of five tertiary hospitals in China. Of these, the data from 70% of patients was randomly selected to derive the model and the other 30% for model validation. A TIPS of \"2\" was indicative of high inflammation and thrombosis biomarkers and \"1\" of one biomarker, with \"0\" indicative of absence of biomarkers. Multivariate logistic regression analyses were used to identify the association between TIPS and SAP.
UNASSIGNED: The TIPS was an independent predictor of SAP and 90-day mortality, with the incidence of SAP being significantly higher for patients with a high TIPS. The TIPS provided superior predictive value for SAP than clinical scores (A2DS2) and biomarkers currently used in practice, for both the derivation and validation sets. Mediation analysis revealed that TIPS provided a predictive value than either thrombotic (NLR) and inflammatory (D-dimer) biomarkers alone.
UNASSIGNED: The TIPS score may be a useful tool for early identification of patients at high-risk for SAP after IS.
UNASSIGNED: The study population consisted of 897 patients with a first diagnosis of IS admitted to the emergency department of five tertiary hospitals in China. Of these, the data from 70% of patients was randomly selected to derive the model and the other 30% for model validation. A TIPS of \"2\" was indicative of high inflammation and thrombosis biomarkers and \"1\" of one biomarker, with \"0\" indicative of absence of biomarkers. Multivariate logistic regression analyses were used to identify the association between TIPS and SAP.
UNASSIGNED: The TIPS was an independent predictor of SAP and 90-day mortality, with the incidence of SAP being significantly higher for patients with a high TIPS. The TIPS provided superior predictive value for SAP than clinical scores (A2DS2) and biomarkers currently used in practice, for both the derivation and validation sets. Mediation analysis revealed that TIPS provided a predictive value than either thrombotic (NLR) and inflammatory (D-dimer) biomarkers alone.
UNASSIGNED: The TIPS score may be a useful tool for early identification of patients at high-risk for SAP after IS.
摘要：
■炎症和血栓形成与卒中相关性肺炎（SAP）的发展有关。我们的目的是评估小说的预测价值，简化，结合缺血性卒中（IS）早期炎症和血栓生物标志物的血栓-炎症预后评分（TIPS）。
■研究人群包括中国五家三级医院急诊科收治的897例首次诊断为IS的患者。其中,随机选择70%患者的数据来推导模型,另外30%用于模型验证.“2”的TIPS指示高度炎症和血栓形成的生物标志物和“1”的一个生物标志物，与\“0\”指示缺乏生物标志物。使用多变量逻辑回归分析来确定TIPS与SAP之间的关联。
■TIPS是SAP和90天死亡率的独立预测因子，高TIPS患者的SAP发生率明显更高。TIPS对SAP的预测价值优于临床评分（A2DS2）和目前在实践中使用的生物标志物。用于派生集和验证集。中介分析显示，TIPS比单独的血栓形成（NLR）和炎症（D-二聚体）生物标志物提供了预测价值。
■TIPS评分可能是早期识别IS后SAP高危患者的有用工具。
■研究人群包括中国五家三级医院急诊科收治的897例首次诊断为IS的患者。其中,随机选择70%患者的数据来推导模型,另外30%用于模型验证.“2”的TIPS指示高度炎症和血栓形成的生物标志物和“1”的一个生物标志物，与\“0\”指示缺乏生物标志物。使用多变量逻辑回归分析来确定TIPS与SAP之间的关联。
■TIPS是SAP和90天死亡率的独立预测因子，高TIPS患者的SAP发生率明显更高。TIPS对SAP的预测价值优于临床评分（A2DS2）和目前在实践中使用的生物标志物。用于派生集和验证集。中介分析显示，TIPS比单独的血栓形成（NLR）和炎症（D-二聚体）生物标志物提供了预测价值。
■TIPS评分可能是早期识别IS后SAP高危患者的有用工具。
