PDF(Pubmed)
Abstract：
The anti-GQ1b IgG antibody is often accompanied by other anti-ganglioside antibodies, which induces various neurological symptoms. We herein report a patient with anti-ganglioside antibodies, including anti-GQ1b IgG and anti-GT1a IgG antibodies, showing bilateral ophthalmoplegia, facial nerve palsies, dysarthria, dysphagia, dysesthesia in both hands, and enhancement of the bilateral oculomotor, abducens, and facial nerves on gadolinium (Gd)-enhanced T1-weighted brain magnetic resonance imaging (MRI). He was first treated with intravenous immunoglobulin, which improved ophthalmoplegia, bulbar palsies, and dysesthesia of hands, but the facial nerve palsies worsened, and Gd enhancement of the brain nerves persisted. High-dose methylprednisolone therapy subsequently improved the facial nerve palsies and Gd enhancement of the cranial nerves. This is the first case with anti-ganglioside antibodies presenting with multiple cranial nerve palsies that was followed to track the changes in the Gd enhancement of cranial nerves on MRI.
摘要：
抗GQ1bIgG抗体常伴有其他抗神经节苷脂抗体，诱发各种神经症状.我们在此报告了一名患有抗神经节苷脂抗体的患者，包括抗GQ1bIgG和抗GT1aIgG抗体，显示双侧眼肌麻痹，面神经麻痹,构音障碍,吞咽困难,两只手的感觉障碍，双侧动眼增强，绑架者,a（Gd）增强的T1加权脑磁共振成像（MRI）和面神经。他首先接受了静脉注射免疫球蛋白治疗，改善了眼肌麻痹，球麻痹,和手的感觉障碍，但是面神经麻痹恶化了，脑神经的Gd增强持续存在。大剂量甲基强的松龙治疗随后改善了面神经麻痹和颅神经的Gd增强。这是首例抗神经节苷脂抗体出现多个颅神经麻痹的病例，随后在MRI上追踪颅神经Gd增强的变化。
