PDF(Pubmed)
Abstract：
UNASSIGNED: To determine the drop volume and total number of dispensed drops using the Nanodropper eyedrop bottle adaptor (Nanodropper, Inc.) compared to drops dispensed from stock bottles to potentially limit ocular toxicity of these eyedrops and prolong bottle use.
UNASSIGNED: Six topical ocular hypotensive medications (5 solutions, 1 suspension), one steroid (suspension) and two artificial tears emulsions were selected for this study. An analytical balance was used to determine the mass per 10 drops with and without the volume-reducing adaptor and repeated until the bottles were completely emptied. The density of each product was determined using the calculated density. The average drop volume and number of drops per bottle for the nine medications were compared with and without the adaptor with paired t-testing.
UNASSIGNED: When all medications were assessed, the drops delivered with the adaptor were 62.1% smaller than eyedrops administered from standard bottles. Compared to stock bottle eyedrops, which had a mean volume of 39.8 ± 2.1 μL, the adaptor resulted in drops with a mean volume of 15.1 ± 1.0 μL, p<0.0001. The adaptor delivered 2.6x the number of drops dispensed from a standard 2.5 mL bottle (184.1 ± 15.1 drops with adaptor and 69.8 ± 4.9 drops from stock bottle, p<0.0001).
UNASSIGNED: The Nanodropper eyedrop bottle adaptor can significantly reduce drop volume and increase the overall number of drops dispensed compared with stock eyedrop bottles. Further studies are needed to elucidate the clinical impact of utilizing decreased drop volume with direct comparison to current standards of care.
UNASSIGNED: Six topical ocular hypotensive medications (5 solutions, 1 suspension), one steroid (suspension) and two artificial tears emulsions were selected for this study. An analytical balance was used to determine the mass per 10 drops with and without the volume-reducing adaptor and repeated until the bottles were completely emptied. The density of each product was determined using the calculated density. The average drop volume and number of drops per bottle for the nine medications were compared with and without the adaptor with paired t-testing.
UNASSIGNED: When all medications were assessed, the drops delivered with the adaptor were 62.1% smaller than eyedrops administered from standard bottles. Compared to stock bottle eyedrops, which had a mean volume of 39.8 ± 2.1 μL, the adaptor resulted in drops with a mean volume of 15.1 ± 1.0 μL, p<0.0001. The adaptor delivered 2.6x the number of drops dispensed from a standard 2.5 mL bottle (184.1 ± 15.1 drops with adaptor and 69.8 ± 4.9 drops from stock bottle, p<0.0001).
UNASSIGNED: The Nanodropper eyedrop bottle adaptor can significantly reduce drop volume and increase the overall number of drops dispensed compared with stock eyedrop bottles. Further studies are needed to elucidate the clinical impact of utilizing decreased drop volume with direct comparison to current standards of care.
摘要：
■要使用Nanodropper滴眼液瓶适配器（Nanodropper，Inc.）与从库存瓶中分配的滴剂相比，潜在地限制了这些滴眼剂的眼部毒性并延长了瓶的使用时间。
■六种局部降眼压药物（5种解决方案，1个暂停),本研究选择了一种类固醇（悬浮液）和两种人工泪液乳液。使用分析天平来确定具有和不具有体积减小的适配器的每10滴的质量,并且重复直到瓶子完全清空。使用计算的密度确定每种产品的密度。将9种药物的平均滴体积和每瓶滴数用配对t检验与不使用适配器进行比较。
■当评估所有药物时，使用适配器递送的滴剂比从标准瓶施用的滴剂小62.1%。与库存瓶眼药水相比，平均体积为39.8±2.1μL，适配器产生的液滴平均体积为15.1±1.0μL，p<0.0001。适配器从标准2.5mL瓶中分配的滴数为2.6倍（使用适配器的滴数为184.1±15.1，从库存瓶中滴数为69.8±4.9，p<0.0001)。
■与库存滴眼液瓶相比，Nanodropper滴眼液瓶适配器可显着减少液滴体积并增加分配的液滴总数。需要进一步的研究来阐明与当前的护理标准直接比较，利用减少的液滴体积的临床影响。
■六种局部降眼压药物（5种解决方案，1个暂停),本研究选择了一种类固醇（悬浮液）和两种人工泪液乳液。使用分析天平来确定具有和不具有体积减小的适配器的每10滴的质量,并且重复直到瓶子完全清空。使用计算的密度确定每种产品的密度。将9种药物的平均滴体积和每瓶滴数用配对t检验与不使用适配器进行比较。
■当评估所有药物时，使用适配器递送的滴剂比从标准瓶施用的滴剂小62.1%。与库存瓶眼药水相比，平均体积为39.8±2.1μL，适配器产生的液滴平均体积为15.1±1.0μL，p<0.0001。适配器从标准2.5mL瓶中分配的滴数为2.6倍（使用适配器的滴数为184.1±15.1，从库存瓶中滴数为69.8±4.9，p<0.0001)。
■与库存滴眼液瓶相比，Nanodropper滴眼液瓶适配器可显着减少液滴体积并增加分配的液滴总数。需要进一步的研究来阐明与当前的护理标准直接比较，利用减少的液滴体积的临床影响。
