PDF(Pubmed)
Abstract：
Selenium (Se) is an essential trace element for the human body. Serum Se and urinary Se are also biomarkers to assess Se exposure status. However, studies focusing on the association between urinary Se and the risk of gestational diabetes mellitus (GDM) are rare.
To investigate the association between urinary Se and the risk of GDM.
A nested case-control study based on a prospective birth cohort in Wuhan, China, which focuses on the effects of prenatal environmental factors exposure on pregnant women and children\'s health was conducted. Two hundred and twenty-six cases and 452 controls were included. Maternal urine samples were collected before GDM diagnosis, and the urinary Se levels were determined. We assessed the association of urinary Se with GDM by conditional logistic regression with maternal urinary Se level as a categorical variable, and estimated the association between Se and glucose levels by multiple linear regression. The potential modifier roles of maternal age and fetal sex have also been assessed.
Lower urinary level of Se was significantly associated with a higher risk of GDM (OR = 2.35 for the tertile 1, 95% CI:1.36-4.06; adjusted OR = 1.79 for the tertile 2, 95%CI:1.09-2.95; p for trend = 0.01). Fetal sex had an interaction with Se in the association with GDM. The association was more pronounced among pregnant women with female fetuses than with male fetuses.
Our study suggested a significant negative association between urinary Se and the risk of GDM, and this association may vary depending on the fetal sex.
To investigate the association between urinary Se and the risk of GDM.
A nested case-control study based on a prospective birth cohort in Wuhan, China, which focuses on the effects of prenatal environmental factors exposure on pregnant women and children\'s health was conducted. Two hundred and twenty-six cases and 452 controls were included. Maternal urine samples were collected before GDM diagnosis, and the urinary Se levels were determined. We assessed the association of urinary Se with GDM by conditional logistic regression with maternal urinary Se level as a categorical variable, and estimated the association between Se and glucose levels by multiple linear regression. The potential modifier roles of maternal age and fetal sex have also been assessed.
Lower urinary level of Se was significantly associated with a higher risk of GDM (OR = 2.35 for the tertile 1, 95% CI:1.36-4.06; adjusted OR = 1.79 for the tertile 2, 95%CI:1.09-2.95; p for trend = 0.01). Fetal sex had an interaction with Se in the association with GDM. The association was more pronounced among pregnant women with female fetuses than with male fetuses.
Our study suggested a significant negative association between urinary Se and the risk of GDM, and this association may vary depending on the fetal sex.
摘要：
■硒（Se）是人体必需的微量元素。血清Se和尿Se也是评估Se暴露状态的生物标志物。然而,关注尿硒与妊娠期糖尿病（GDM）风险之间关联的研究很少。
■探讨尿硒与GDM发病风险的关系。
■一项基于武汉市前瞻性出生队列的巢式病例对照研究，中国,重点研究了产前环境因素暴露对孕妇和儿童健康的影响。包括226例病例和452例对照。在GDM诊断前收集母体尿液样本，并测定尿硒水平。我们通过条件logistic回归以母体尿硒水平为分类变量，评估了尿硒与GDM的相关性，并通过多元线性回归估计硒和葡萄糖水平之间的关联。还评估了母亲年龄和胎儿性别的潜在修饰作用。
■低尿硒水平与较高的GDM风险显着相关（三元组1的OR=2.35，95％CI：1.36-4.06；三元组2的校正OR=1.79，95CI：1.09-2.95；趋势p=0.01）。在与GDM的关系中，胎儿性别与Se有相互作用。与男性胎儿相比，女性胎儿的孕妇之间的关联更为明显。
■我们的研究表明，尿硒与GDM风险之间存在显著的负相关，这种关联可能因胎儿性别而异。
■探讨尿硒与GDM发病风险的关系。
■一项基于武汉市前瞻性出生队列的巢式病例对照研究，中国,重点研究了产前环境因素暴露对孕妇和儿童健康的影响。包括226例病例和452例对照。在GDM诊断前收集母体尿液样本，并测定尿硒水平。我们通过条件logistic回归以母体尿硒水平为分类变量，评估了尿硒与GDM的相关性，并通过多元线性回归估计硒和葡萄糖水平之间的关联。还评估了母亲年龄和胎儿性别的潜在修饰作用。
■低尿硒水平与较高的GDM风险显着相关（三元组1的OR=2.35，95％CI：1.36-4.06；三元组2的校正OR=1.79，95CI：1.09-2.95；趋势p=0.01）。在与GDM的关系中，胎儿性别与Se有相互作用。与男性胎儿相比，女性胎儿的孕妇之间的关联更为明显。
■我们的研究表明，尿硒与GDM风险之间存在显著的负相关，这种关联可能因胎儿性别而异。
