The scoping review will follow Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for scoping review. A comprehensive search of the literature will be conducted in MEDLINE, Embase, Cochrane, Scopus and Web of Science. The search strategy will include terms related to IVCM, diabetes and corneal nerve fibres. We will set inclusion and exclusion criteria prior to the search, and two reviewers will screen titles and abstracts independently. One reviewer will full text read eligible articles and chart data from the studies. A descriptive summary of the methods used in imaging, image processing and quantitative analysis of peripheral corneal nerve fibres by IVCM will be written.
Ethical approval is not required since this is a scoping review based on previously published articles. The findings will be published in a scientific peer-reviewed journal.
方法:范围审查将遵循系统审查的首选报告项目和范围审查的荟萃分析指南。将在MEDLINE中对文献进行全面搜索,Embase,科克伦,Scopus和WebofScience搜索策略将包括与IVCM相关的术语,糖尿病和角膜神经纤维。我们将在搜索之前设定纳入和排除标准,两名审稿人将独立筛选标题和摘要。一位审阅者将全文阅读研究中符合条件的文章和图表数据。成像中使用的方法的描述性总结,将通过IVCM对周围角膜神经纤维进行图像处理和定量分析。
背景:不需要道德批准,因为这是基于先前发表的文章的范围审查。研究结果将发表在科学同行评审的期刊上。