Abstract：
Left-right (LR) asymmetry of the brain is fundamental to its higher-order functions. The Drosophila brain\'s asymmetrical body (AB) consists of a structural pair arborized from AB neurons and is larger on the right side than the left. We find that the AB initially forms LR symmetrically and then develops LR asymmetrically by neurite remodeling that is specific to the left AB and is dynamin dependent. Additionally, neuronal ecdysone signaling inhibition randomizes AB laterality, suggesting that ecdysone signaling determines AB\'s LR polarity. Given that AB\'s LR asymmetry relates to memory formation, our research establishes AB as a valuable model for studying LR asymmetry and higher-order brain function relationships.
摘要：
大脑的左右（LR）不对称性是其高阶功能的基础。果蝇大脑的不对称体（AB）由由AB神经元构成的结构对组成，右侧比左侧大。我们发现，AB最初对称地形成LR，然后通过神经突重塑不对称地发展LR，神经突重塑是左侧AB特有的，并且依赖于动力蛋白。此外,神经元蜕皮激素信号抑制随机化AB侧向性，这表明蜕皮激素信号决定了AB的LR极性。鉴于AB的LR不对称性与记忆形成有关，我们的研究将AB确立为研究LR不对称性和高阶脑功能关系的有价值的模型.
