Abstract：
Proper eye structure is essential for visual function: Multiple essential eye tissues must take shape and assemble into a precise three-dimensional configuration. Accordingly, alterations to eye structure can lead to pathological conditions of visual impairment. Changes in eye shape can also be adaptive over evolutionary time. Eye structure is first established during development with the formation of the optic cup, which contains the neural retina, retinal pigment epithelium, and lens. This crucial yet deceptively simple hemispherical structure lays the foundation for all later elaborations of the eye. Building on descriptions of the embryonic eye that started with hand drawings and micrographs, the field is beginning to identify mechanisms driving dynamic changes in three-dimensional cell and tissue shape. A combination of molecular genetics, imaging, and pharmacological approaches is defining connections among transcription factors, signaling pathways, and the intracellular machinery governing the emergence of this crucial structure.
摘要：
正确的眼睛结构对于视觉功能至关重要：多个基本的眼睛组织必须成形并组装成精确的三维结构。因此，眼睛结构的改变可导致视觉障碍的病理状况。眼睛形状的变化也可以随进化时间而适应。眼睛结构首先是在发育过程中随着视杯的形成而建立的，包含神经视网膜，视网膜色素上皮,和镜头。这种关键但看似简单的半球形结构为以后的所有眼睛细节奠定了基础。基于从手绘和显微照片开始的胚胎眼描述，该领域开始识别驱动三维细胞和组织形状动态变化的机制。分子遗传学的结合，成像,药理学方法是定义转录因子之间的联系，信号通路，和细胞内机制控制着这个关键结构的出现。视觉科学年度评论的预期最终在线出版日期，第9卷是2023年9月。请参阅http://www。annualreviews.org/page/journal/pubdates的订正估计数。
