Abstract：
OBJECTIVE: To compare the VEGF levels in the aqueous humor of patients with Primary Open Angle Glaucoma (POAG) and non-glaucomatous eyes and reveal any potential statistically significant correlations.
METHODS: We searched PubMed, from inception to December 31, 2021. Key search terms included VEGF and Glaucoma. All relevant studies that evaluated the VEGF levels in patients with POAG and in the control group were included in this systematic review. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA) guidelines were followed. Data were extracted independently by 2 authors. Heterogeneity was statistically quantified by Q, H, and I2 statistics, and a meta-analysis was performed using the random-effects model.
RESULTS: Seven cross-sectional studies were included in the meta-analysis. 144 eyes were enrolled in the POAG group and 162 eyes in the control group. The random effect model showed no statistically significant difference between the two groups (SMD =0.284, 95% CI = -0.173 to 0.741; P = 0.223), but we noticed a trend towards elevated VEGF levels in the aqueous humor of POAG patients. Significant heterogeneity was detected (I2 = 74.1%, P = 0.001).
CONCLUSIONS: This systematic review and meta-analysis indicates a trend towards elevated VEGF-A levels in the aqueous humor of patients with POAG and suggests a potential neuroprotective role of VEGF in patients with POAG. Future studies are required to evaluate the exact role of VEGF in POAG.
METHODS: We searched PubMed, from inception to December 31, 2021. Key search terms included VEGF and Glaucoma. All relevant studies that evaluated the VEGF levels in patients with POAG and in the control group were included in this systematic review. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis of Diagnostic Test Accuracy Studies (PRISMA-DTA) guidelines were followed. Data were extracted independently by 2 authors. Heterogeneity was statistically quantified by Q, H, and I2 statistics, and a meta-analysis was performed using the random-effects model.
RESULTS: Seven cross-sectional studies were included in the meta-analysis. 144 eyes were enrolled in the POAG group and 162 eyes in the control group. The random effect model showed no statistically significant difference between the two groups (SMD =0.284, 95% CI = -0.173 to 0.741; P = 0.223), but we noticed a trend towards elevated VEGF levels in the aqueous humor of POAG patients. Significant heterogeneity was detected (I2 = 74.1%, P = 0.001).
CONCLUSIONS: This systematic review and meta-analysis indicates a trend towards elevated VEGF-A levels in the aqueous humor of patients with POAG and suggests a potential neuroprotective role of VEGF in patients with POAG. Future studies are required to evaluate the exact role of VEGF in POAG.
摘要：
目的：比较原发性开角型青光眼（POAG）和非青光眼患者房水中的VEGF水平，并揭示任何潜在的统计学意义上的相关性。
方法：我们搜索了PubMed，从成立到2021年12月31日。关键搜索项包括VEGF和青光眼。评估POAG患者和对照组VEGF水平的所有相关研究都包括在此系统评价中。遵循诊断测试准确性研究（PRISMA-DTA）指南的系统审查和荟萃分析的首选报告项目。数据由2名作者独立提取。异质性通过Q进行统计量化，H,和I2统计数据，采用随机效应模型进行荟萃分析.
结果：7项横断面研究纳入荟萃分析。POAG组144只眼，对照组162只眼。随机效应模型两组间差异无统计学意义(SMD=0.284,95%CI=-0.173~0.741;P=0.223),但是我们注意到POAG患者房水中VEGF水平有升高的趋势.检测到显著的异质性(I2=74.1%，P=0.001)。
结论：本系统综述和荟萃分析提示POAG患者房水VEGF-A水平有升高的趋势，提示VEGF在POAG患者中具有潜在的神经保护作用。需要进一步的研究来评估VEGF在POAG中的确切作用。
方法：我们搜索了PubMed，从成立到2021年12月31日。关键搜索项包括VEGF和青光眼。评估POAG患者和对照组VEGF水平的所有相关研究都包括在此系统评价中。遵循诊断测试准确性研究（PRISMA-DTA）指南的系统审查和荟萃分析的首选报告项目。数据由2名作者独立提取。异质性通过Q进行统计量化，H,和I2统计数据，采用随机效应模型进行荟萃分析.
结果：7项横断面研究纳入荟萃分析。POAG组144只眼，对照组162只眼。随机效应模型两组间差异无统计学意义(SMD=0.284,95%CI=-0.173~0.741;P=0.223),但是我们注意到POAG患者房水中VEGF水平有升高的趋势.检测到显著的异质性(I2=74.1%，P=0.001)。
结论：本系统综述和荟萃分析提示POAG患者房水VEGF-A水平有升高的趋势，提示VEGF在POAG患者中具有潜在的神经保护作用。需要进一步的研究来评估VEGF在POAG中的确切作用。
