PDF(Pubmed)
Abstract：
Osteosarcopenia is a burgeoning geriatric syndrome and a familiar disease among older individuals. It is characterized by reduced skeletal muscle mass and bone mineral density due to osteoporosis and sarcopenia. Its clinical manifestations include reduced physical performance and individuals becoming prone to falls during the aging process resulting in fractures and hospitalization, which seriously affects the quality of life of patients and increases the risk of death. Due to the aging social structure of the global population, the morbidity of osteosarcopenia is expected to continue to increase. Both muscle and bone belong to the motor system and originate from the mesoderm; therefore, sarcopenia and osteoporosis also share similar pathogenical factors, which influence and regulate each other. Studying the pathogenesis and treatment of osteosarcopenia is of great significance to improve the quality of life of patients. Therefore, the present study reviewed the research progress on sarcopenia and osteoporosis in osteosarcopenia from the standpoints of its definition, epidemiology, clinical manifestations and diagnosis, prevention and treatment.
摘要：
骨质减少症是一种新兴的老年综合征，是老年人中常见的疾病。它的特征是由于骨质疏松症和少肌症导致的骨骼肌质量和骨矿物质密度降低。其临床表现包括身体机能下降和个体在衰老过程中容易跌倒，导致骨折和住院，严重影响患者的生活质量,增加死亡风险。由于全球人口老龄化的社会结构,骨肉瘤的发病率预计将继续增加。肌肉和骨骼都属于运动系统，起源于中胚层；因此，肌肉减少症和骨质疏松症也有相似的致病因素，相互影响和调节。研究骨肉瘤的发病机制及治疗方法对提高患者的生活质量具有重要意义。因此,本研究从骨肉瘤的定义角度综述了骨肉瘤和骨质疏松的研究进展，流行病学,临床表现和诊断，预防和治疗。
