Abstract：
Hemolytic disease of the fetus and newborn (HDFN) due to anti-D was severe and fatal before the development of RhD immune prophylaxis. Proper screening and universal administration of Rh immune globulin has decreased the incidence of HDFN to a great extent. Pregnancy, transfusion, and transplantation still increase the chances of other alloantibody formation and the potential for HDFN. Advanced methods for immunohematology investigation allow for the identification of alloantibodies causative for HDFN other than anti-D. Many antibodies have been reported to cause HDFN, but there is scant literature where isolated anti-C is responsible for HDFN. We present here a case of severe HDFN caused by anti-C leading to severe hydrops and death of the neonate despite three intrauterine transfusions and other measures.
摘要：
在发展RhD免疫预防之前，由于抗D引起的胎儿和新生儿溶血病（HDFN）是严重且致命的。正确筛查和普遍使用Rh免疫球蛋白在很大程度上降低了HDFN的发病率。怀孕,输血,和移植仍然增加其他同种抗体形成的机会和HDFN的潜力。用于免疫血液学研究的先进方法允许鉴定除抗D以外的引起HDFN的同种抗体。据报道，许多抗体会导致HDFN，但是很少有文献表明分离的抗C是HDFN的原因。我们在此介绍一例由抗C引起的严重HDFN，尽管进行了三次宫内输血和其他措施，但仍导致新生儿严重积水和死亡。
