METHODS: The Cochrane, PubMed, EMBASE, and Medline (Ovid) databases were searched for the relevant studies from the date of inception to August 2022. Case-control, cross-sectional, and cohort studies examining the effects of cosmetic/personal care product use on FFA, available in English full-text, were included. Analyses were performed using Review Manager, version 5.4. Results were reported as an odds ratio (OR) with a 95% confidence interval (CI); p values < 0.05 were considered significant.
RESULTS: Nine studies were included in our quantitative analyses, totaling 1,248 FFA patients and 1,459 controls. There were significant positive associations found for FFA and sunscreen (OR 3.02, 95% CI 1.67-5.47; p = 0.0003) and facial moisturizer (OR 2.20, 95% CI 1.51-3.20; p < 0.0001) use. Gender sub-analyses demonstrated a positive association for FFA and facial moisturizer in men (OR 5.07, 95% CI 1.40-18.32; p = 0.01), but not in women (OR 1.58, 95% CI 0.83-2.98; p = 0.16). Both gender sub-analyses were significantly positive for the association with facial sunscreen (Male OR 4.61, 95% CI 1.54-13.78, p = 0.006; Female OR 2.74, 95% CI 1.32-5.70, p = 0.007). There was no association found for a facial cleanser (OR 1.14, 95% CI 0.33-1.52; p = 0.51), foundation (OR 1.13, 95% CI 0.83-1.55; p = 0.21), shampoo (OR 0.49, 95% CI 0.22-1.10; p = 0.08), hair conditioner (OR 0.81, 95% CI 0.52-1.26; p = 0.35), hair mousse (OR 1.37, 95% CI 0.75-2.51; p = 0.31), and hair gel (OR 0.90, 95% CI 0.48-1.69; p = 0.74), hair dye (OR 1.07, 95% CI 0.69-1.64; p = 0.77), hair straightening/rebonding (OR 0.88, 95% CI 0.08-9.32; p = 0.92), hair perming (OR 1.41, 95% CI 0.89-2.23; p = 0.14), facial toner (OR 0.51, 95% CI 0.12-2.21; p = 0.37), or aftershave (OR 1.64, 95% CI 0.28-9.49; p = 0.58).
CONCLUSIONS: This meta-analysis strongly suggests that leave-on facial products, facial sunscreen and moisturizer, are associated with FFA. While the association with facial moisturizer did not persist when stratifying for female populations, gender sub-analyses remained significant for a facial sunscreen. There was no significant relationship found with hair products or treatments. These findings suggest a potential environmental etiology in the development of FFA, particularly UV-protecting chemicals.
方法:Cochrane,PubMed,EMBASE,和Medline(Ovid)数据库从研究开始之日起至2022年8月的相关研究进行了搜索.病例控制,横截面,和队列研究检查化妆品/个人护理产品的使用对FFA的影响,以英文全文提供,包括在内。使用ReviewManager进行分析,版本5.4。结果报告为比值比(OR),置信区间为95%(CI);p值<0.05被认为是显着的。
结果:我们的定量分析包括9项研究,共有1,248名FFA患者和1,459名对照。发现FFA和防晒霜(OR3.02,95%CI1.67-5.47;p=0.0003)和面部保湿剂(OR2.20,95%CI1.51-3.20;p<0.0001)的使用存在显着正相关。性别分分析显示男性FFA和面部保湿剂呈正相关(OR5.07,95%CI1.40-18.32;p=0.01),但女性并非如此(OR1.58,95%CI0.83-2.98;p=0.16)。两种性别分分析均与面部防晒霜呈显著正相关(男性OR4.61,95%CI1.54-13.78,p=0.006;女性OR2.74,95%CI1.32-5.70,p=0.007)。没有发现洗面奶的相关性(OR1.14,95%CI0.33-1.52;p=0.51),地基(OR1.13,95%CI0.83-1.55;p=0.21),洗发水(OR0.49,95%CI0.22-1.10;p=0.08),护发素(OR0.81,95%CI0.52-1.26;p=0.35),头发摩丝(OR1.37,95%CI0.75-2.51;p=0.31),和发胶(OR0.90,95%CI0.48-1.69;p=0.74),染发剂(OR1.07,95%CI0.69-1.64;p=0.77),头发拉直/重新粘合(OR0.88,95%CI0.08-9.32;p=0.92),烫发(OR1.41,95%CI0.89-2.23;p=0.14),面部爽肤水(OR0.51,95%CI0.12-2.21;p=0.37),或须后水(OR1.64,95%CI0.28-9.49;p=0.58)。
结论:这项荟萃分析强烈表明,保留面部产品,面部防晒霜和保湿霜,与FFA有关。虽然对女性人群进行分层时,与面部保湿剂的关联并不持续,性别分分析对于面部防晒霜仍然具有重要意义。没有发现与头发产品或治疗的显着关系。这些发现表明FFA发展中潜在的环境病因,特别是保护紫外线的化学品。