Abstract：
OBJECTIVE: To investigate the effectiveness of low-dose aspirin (LDA) in the prevention of pre-eclampsia (PE) among otherwise low-risk twin gestations.
METHODS: A historical cohort study consisting of all pregnant individuals with dichorionic diamniotic (DCDA) twin pregnancy who delivered between 2014 and 2020. Patients treated with LDA were matched by a 1:4 ratio to individuals who were not treated with LDA by age, body mass index and parity.
RESULTS: During the study period, 2271 individuals carrying DCDA pregnancies delivered at our center. Of these, 404 were excluded for one or more additional major risk factors. The remaining cohort consisted of 1867 individuals of whom 142 (7.6%) were treated with LDA and were compared with a 1:4 matched group of 568 individuals who were not treated. The rate of preterm PE did not differ significantly between the two groups (18 [12.7%] in the LDA group vs. 55 [9.7%] in the no-LDA group; P = 0.294, adjusted odds ratio 1.36, 95% confidence interval 0.77-2.40). There were no other significant between-group differences.
CONCLUSIONS: Low-dose aspirin treatment in pregnant individuals with DCDA twin gestations without additional major risk factors was not associated with a reduction in the rate of preterm PE.
METHODS: A historical cohort study consisting of all pregnant individuals with dichorionic diamniotic (DCDA) twin pregnancy who delivered between 2014 and 2020. Patients treated with LDA were matched by a 1:4 ratio to individuals who were not treated with LDA by age, body mass index and parity.
RESULTS: During the study period, 2271 individuals carrying DCDA pregnancies delivered at our center. Of these, 404 were excluded for one or more additional major risk factors. The remaining cohort consisted of 1867 individuals of whom 142 (7.6%) were treated with LDA and were compared with a 1:4 matched group of 568 individuals who were not treated. The rate of preterm PE did not differ significantly between the two groups (18 [12.7%] in the LDA group vs. 55 [9.7%] in the no-LDA group; P = 0.294, adjusted odds ratio 1.36, 95% confidence interval 0.77-2.40). There were no other significant between-group differences.
CONCLUSIONS: Low-dose aspirin treatment in pregnant individuals with DCDA twin gestations without additional major risk factors was not associated with a reduction in the rate of preterm PE.
摘要：
目的：研究低剂量阿司匹林（LDA）在低风险双胎妊娠中预防先兆子痫（PE）的有效性。
方法：一项历史队列研究，包括2014年至2020年期间分娩的所有双胎双胎（DCDA）双胎妊娠孕妇。用LDA治疗的患者按年龄1:4的比例与未用LDA治疗的个体相匹配。体重指数和奇偶校验。
结果：在研究期间，2271名携带DCDA怀孕的人在我们中心分娩。其中,404人被排除在一个或多个其他主要危险因素之外。其余队列由1867名个体组成，其中142名（7.6％）接受了LDA治疗，并与未接受治疗的568名个体的1：4匹配组进行了比较。两组之间的早产PE率没有显着差异（LDA组的18[12.7％]与无LDA组55[9.7%]；P=0.294，调整后比值比1.36，95%置信区间0.77-2.40）。组间没有其他显著差异。
结论：在没有其他主要危险因素的DCDA双胎妊娠患者中，低剂量阿司匹林治疗与早产PE发生率的降低无关。
方法：一项历史队列研究，包括2014年至2020年期间分娩的所有双胎双胎（DCDA）双胎妊娠孕妇。用LDA治疗的患者按年龄1:4的比例与未用LDA治疗的个体相匹配。体重指数和奇偶校验。
结果：在研究期间，2271名携带DCDA怀孕的人在我们中心分娩。其中,404人被排除在一个或多个其他主要危险因素之外。其余队列由1867名个体组成，其中142名（7.6％）接受了LDA治疗，并与未接受治疗的568名个体的1：4匹配组进行了比较。两组之间的早产PE率没有显着差异（LDA组的18[12.7％]与无LDA组55[9.7%]；P=0.294，调整后比值比1.36，95%置信区间0.77-2.40）。组间没有其他显著差异。
结论：在没有其他主要危险因素的DCDA双胎妊娠患者中，低剂量阿司匹林治疗与早产PE发生率的降低无关。
