PDF(Pubmed)
Abstract：
OBJECTIVE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.
METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.
RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.
CONCLUSIONS: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.
RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.
CONCLUSIONS: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
摘要：
目的：目的是研究双峰光学和放射引导前哨淋巴结活检（SNB）对口腔前牙鳞状细胞癌（OSCC）亚部位的诊断性能。
方法：对50例计划进行SNB的cN0OSCC连续患者进行前瞻性研究，并注射示踪剂复合物Tc99m：ICG：Nacocoll。近红外相机用于光学SN检测。终点是术中SN检测的方式和随访时的误漏率。
结果：在所有患者中，可以检测到SN。在12/50(24%)的病例中，SPECT/CT显示1级无病灶,但术中光学检测到1级SN.在22/50例（44%）中，仅由于光学成像而识别出额外的SN。在后续行动中,误报率为0%。
结论：光学成像似乎是允许实时SN识别的有效工具，包括1级不受注射辐射部位可能干扰的影响。
方法：对50例计划进行SNB的cN0OSCC连续患者进行前瞻性研究，并注射示踪剂复合物Tc99m：ICG：Nacocoll。近红外相机用于光学SN检测。终点是术中SN检测的方式和随访时的误漏率。
结果：在所有患者中，可以检测到SN。在12/50(24%)的病例中，SPECT/CT显示1级无病灶,但术中光学检测到1级SN.在22/50例（44%）中，仅由于光学成像而识别出额外的SN。在后续行动中,误报率为0%。
结论：光学成像似乎是允许实时SN识别的有效工具，包括1级不受注射辐射部位可能干扰的影响。
