{Reference Type}: Journal Article
{Title}: Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity.
{Author}: Christensen A;Wessel I;Charabi BW;Juhl K;Kiss K;Lelkaitis G;Mortensen J;Kjaer A;von Buchwald C;Tvedskov JF;
{Journal}: Eur Arch Otorhinolaryngol
{Volume}: 280
{Issue}: 7
{Year}: Jul 2023 3
{Factor}: 3.236
{DOI}: 10.1007/s00405-023-07939-5
{Abstract}: <B>OBJECTIVE: </B>The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity.<BR><B>METHODS: </B>Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up.<BR><B>RESULTS: </B>In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%.<BR><B>CONCLUSIONS: </B>Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.