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Abstract：
BACKGROUND: The aim of this study was to determine whether anterior scleral thickness (AST) varies significantly between patients with central serous chorioretinopathy (CSCR) versus normal individuals. To validate scleral thickness measurements by ultrasound biomicroscopy (UBM) vis a vis anterior segment optical coherence tomography (ASOCT).
METHODS: This case-control study analyzed 50 eyes of 50 patients with CSCR (cases) and compared it with that of 50 eyes of 50 age- and gender-matched controls. In cases, AST was measured at 1 mm and 2 mm temporal to the temporal scleral spur by ASOCT and UBM. In controls, AST was measured only by ASOCT. In all participants, posterior choroidal thickness (CT) was measured subfoveally, 1 mm nasal and 1 mm temporal to fovea by enhanced depth imaging optical coherence tomography.
RESULTS: The mean AST, as measured by ASOCT among cases and controls was 703.86 μm and 667.54 μm, respectively (P = 0.006). The mean AST by ASOCT and UBM in cases were 703.86 μm and 657.42 μm, respectively (P = 0.001). AST measurement by ASOCT and UBM showed a positive and statistically significant correlation (r = 0.431, P = 0.000). The mean CT among cases and controls was 443.56 μm and 373.88 μm, respectively (P = 0.000). We found a weak positive correlation (r = 0.11) in cases and weaker positive correlation in controls, between CT and AST measured by ASOCT.
CONCLUSIONS: Our findings suggest that AST varies significantly between patients with CSCR versus normal individuals. We found poor agreement of AST when measured by ASOCT and UBM.
METHODS: This case-control study analyzed 50 eyes of 50 patients with CSCR (cases) and compared it with that of 50 eyes of 50 age- and gender-matched controls. In cases, AST was measured at 1 mm and 2 mm temporal to the temporal scleral spur by ASOCT and UBM. In controls, AST was measured only by ASOCT. In all participants, posterior choroidal thickness (CT) was measured subfoveally, 1 mm nasal and 1 mm temporal to fovea by enhanced depth imaging optical coherence tomography.
RESULTS: The mean AST, as measured by ASOCT among cases and controls was 703.86 μm and 667.54 μm, respectively (P = 0.006). The mean AST by ASOCT and UBM in cases were 703.86 μm and 657.42 μm, respectively (P = 0.001). AST measurement by ASOCT and UBM showed a positive and statistically significant correlation (r = 0.431, P = 0.000). The mean CT among cases and controls was 443.56 μm and 373.88 μm, respectively (P = 0.000). We found a weak positive correlation (r = 0.11) in cases and weaker positive correlation in controls, between CT and AST measured by ASOCT.
CONCLUSIONS: Our findings suggest that AST varies significantly between patients with CSCR versus normal individuals. We found poor agreement of AST when measured by ASOCT and UBM.
摘要：
背景：本研究的目的是确定中央性浆液性脉络膜视网膜病变（CSCR）患者与正常个体的前巩膜厚度（AST）是否有显著差异。通过超声生物显微镜（UBM）与眼前节光学相干断层扫描（ASOCT）验证巩膜厚度的测量。
方法：这项病例对照研究分析了50例CSCR患者（病例）的50只眼，并将其与50例年龄和性别匹配的对照组的50只眼进行了比较。在案例中,通过ASOCT和UBM在距颞侧巩膜骨刺1毫米和2毫米处测量AST。在控件中，AST仅通过ASOCT测量。在所有参与者中,后脉络膜厚度（CT）在中心凹下测量，通过增强深度成像光学相干断层扫描，鼻部1毫米和颞部至中央凹1毫米。
结果：平均AST，根据ASOCT在病例和对照组中的测量，分别为703.86μm和667.54μm，分别为(P=0.006)。ASOCT和UBM的平均AST分别为703.86μm和657.42μm，分别(P=0.001)。ASOCT和UBM的AST检测结果呈正相关(r=0.431,P=0.000)。病例和对照组的平均CT为443.56μm和373.88μm，分别为(P=0.000)。我们发现病例呈弱正相关（r=0.11），对照组呈弱正相关，通过ASOCT测量的CT和AST之间。
结论：我们的研究结果表明，与正常个体相比，CSCR患者的AST有显著差异。当通过ASOCT和UBM测量时，我们发现AST的一致性很差。
方法：这项病例对照研究分析了50例CSCR患者（病例）的50只眼，并将其与50例年龄和性别匹配的对照组的50只眼进行了比较。在案例中,通过ASOCT和UBM在距颞侧巩膜骨刺1毫米和2毫米处测量AST。在控件中，AST仅通过ASOCT测量。在所有参与者中,后脉络膜厚度（CT）在中心凹下测量，通过增强深度成像光学相干断层扫描，鼻部1毫米和颞部至中央凹1毫米。
结果：平均AST，根据ASOCT在病例和对照组中的测量，分别为703.86μm和667.54μm，分别为(P=0.006)。ASOCT和UBM的平均AST分别为703.86μm和657.42μm，分别(P=0.001)。ASOCT和UBM的AST检测结果呈正相关(r=0.431,P=0.000)。病例和对照组的平均CT为443.56μm和373.88μm，分别为(P=0.000)。我们发现病例呈弱正相关（r=0.11），对照组呈弱正相关，通过ASOCT测量的CT和AST之间。
结论：我们的研究结果表明，与正常个体相比，CSCR患者的AST有显著差异。当通过ASOCT和UBM测量时，我们发现AST的一致性很差。
