Abstract：
Associative learning and memory are fundamental behavioral processes through which organisms adapt to complex environments. Associative memory involves long-lasting changes in synaptic plasticity. Dendritic spines are tiny protrusions from the dendritic shaft of principal neurons, providing the structural basis for synaptic plasticity and brain networks in response to external stimuli. Mounting evidence indicates that dendritic spine dynamics are crucial in different associative memory phases, including acquisition, consolidation, and reconsolidation. Causally bridging dendritic spine dynamics and associative memory is still limited by the suitable tools to measure and control spine dynamics in vivo under behaviorally relevant conditions. Here, we review data providing evidence for the remodeling of dendritic spines during associative memory processing and outline open questions.
摘要：
联想学习和记忆是生物体适应复杂环境的基本行为过程。联想记忆涉及突触可塑性的持久变化。树突棘是主要神经元树突轴的微小突起，为响应外部刺激的突触可塑性和大脑网络提供结构基础。越来越多的证据表明，树突状脊柱动力学在不同的联想记忆阶段至关重要，包括收购，合并，和重新整合。在行为相关条件下，在体内测量和控制脊柱动力学的合适工具仍然限制了引起桥接的树突状脊柱动力学和联想记忆。这里,我们回顾了相关数据，这些数据为联想记忆处理过程中树突棘的重塑提供了证据，并概述了开放性问题。
