PDF(Pubmed)
Abstract：
Recurrent intussusception is one of the common acute abdominal diseases in infants, which seriously affects the physical and mental health of infants, but its risk factors have not been fully clarified. The objective of this study was to evaluate the relationship between Th2/Th1 cytokine imbalance and recurrent intussusception, so as to provide a theoretical basis for making a more comprehensive treatment strategy for patients with recurrent intussusception. A retrospective study was conducted between July 2012 and September 2022, enrolling patients with intussusception in Children\'s Hospital of Hebei Province. The patients were divided into recurrent group and non-recurrent group according to whether they suffered from recurrent intussusception. We summarized the clinical characteristics of recurrent intussusception and explored the role of T helper 2 (Th2)/T helper 1 (Th1) cytokine imbalance in it. A total of 2008 patients were initially enrolled and finally 1657 patients qualified for the study. The results showed that the incidence of recurrent intussusception was 18.41% and the Th2/Th1 cytokine imbalance was closely related to the incidence of recurrent intussusception. Th2/Th1 cytokine imbalance is a potential risk factor of recurrent intussusception and more likely to occur in children between the ages of 2 and 3. Future studies are needed to preemptively target the Th2/Th1 cytokine imbalance to formulate a reasonable treatment plan for children with intussusception to avoid recurrence.
摘要：
复发性肠套叠是婴幼儿常见的急腹症之一。严重影响婴儿的身心健康，但其风险因素尚未完全阐明。这项研究的目的是评估Th2/Th1细胞因子失衡与复发性肠套叠之间的关系，为复发性肠套叠患者制定更全面的治疗策略提供理论依据。回顾性研究于2012年7月至2022年9月在河北省儿童医院收治肠套叠患者。根据患者是否复发肠套叠分为复发组和非复发组。我们总结了复发性肠套叠的临床特征，并探讨了T辅助细胞2（Th2）/T辅助细胞1（Th1）细胞因子失衡在其中的作用。最初共招募了2008名患者，最终有1657名患者符合研究条件。结果显示，复发性肠套叠的发生率为18.41%，Th2/Th1细胞因子失衡与复发性肠套叠的发生密切相关。Th2/Th1细胞因子失衡是复发性肠套叠的潜在危险因素，并且更容易发生在2至3岁的儿童中。未来的研究需要针对Th2/Th1细胞因子失衡问题,为肠套叠患儿制定合理的治疗方案,避免复发。
