PDF(Pubmed)
Abstract：
UNASSIGNED: Prostaglandin analogs have been found to have more versatile uses: treatment of open-angle glaucoma, high intraocular pressure, vitiligo, and other treatments. And prostaglandin analogs have been found to have an important role in the hair growth cycle. However, prostaglandin analogs have not been sufficiently studied for hair (including hair, eyelashes, and eyebrows) regeneration. In this study, a systematic review and meta-analysis of topical prostaglandin analogs on hair loss was performed.
UNASSIGNED: The purpose of this meta-analysis is to determine the efficacy and safety of topical prostaglandin analogs for treating hair loss.
UNASSIGNED: We searched PubMed, Embase, and Cochrane Library databases comprehensively. Data were pooled using Review Manager 5.4.1, and subgroup analyses were performed if necessary.
UNASSIGNED: There were six randomized controlled trials included in this meta-analysis. All studies compared prostaglandin analogs with placebo, and one trial consisted of two sets of data. The results showed that prostaglandin analogs could significantly improve the hair length and density (p < 0.001). As far as adverse events are concerned, there was no significant difference between the experimental group and the control group.
UNASSIGNED: In patients with hair loss, the topical prostaglandin analogs have better therapeutic efficacy and safety than placebo. However, the best dose and frequency of experimental treatment require further studies.
UNASSIGNED: The purpose of this meta-analysis is to determine the efficacy and safety of topical prostaglandin analogs for treating hair loss.
UNASSIGNED: We searched PubMed, Embase, and Cochrane Library databases comprehensively. Data were pooled using Review Manager 5.4.1, and subgroup analyses were performed if necessary.
UNASSIGNED: There were six randomized controlled trials included in this meta-analysis. All studies compared prostaglandin analogs with placebo, and one trial consisted of two sets of data. The results showed that prostaglandin analogs could significantly improve the hair length and density (p < 0.001). As far as adverse events are concerned, there was no significant difference between the experimental group and the control group.
UNASSIGNED: In patients with hair loss, the topical prostaglandin analogs have better therapeutic efficacy and safety than placebo. However, the best dose and frequency of experimental treatment require further studies.
摘要：
■已发现前列腺素类似物具有更多的用途：开角型青光眼的治疗，高眼压，白癜风,和其他治疗。并且已经发现前列腺素类似物在毛发生长周期中具有重要作用。然而,前列腺素类似物尚未对头发进行充分研究（包括头发，睫毛,和眉毛）再生。在这项研究中,我们对局部用前列腺素类似物治疗脱发进行了系统评价和荟萃分析.
■本荟萃分析的目的是确定局部前列腺素类似物治疗脱发的功效和安全性。
■我们搜索了PubMed，Embase,和Cochrane图书馆数据库全面。使用ReviewManager5.4.1汇总数据，必要时进行亚组分析。
■本荟萃分析包括6项随机对照试验。所有研究都比较了前列腺素类似物和安慰剂，一项试验由两组数据组成.结果表明，前列腺素类似物可以显着改善头发的长度和密度（p<0.001）。就不良事件而言，实验组与对照组之间无显著性差异。
■在脱发患者中，外用前列腺素类似物比安慰剂具有更好的治疗效果和安全性.然而,实验治疗的最佳剂量和频率需要进一步研究。
■本荟萃分析的目的是确定局部前列腺素类似物治疗脱发的功效和安全性。
■我们搜索了PubMed，Embase,和Cochrane图书馆数据库全面。使用ReviewManager5.4.1汇总数据，必要时进行亚组分析。
■本荟萃分析包括6项随机对照试验。所有研究都比较了前列腺素类似物和安慰剂，一项试验由两组数据组成.结果表明，前列腺素类似物可以显着改善头发的长度和密度（p<0.001）。就不良事件而言，实验组与对照组之间无显著性差异。
■在脱发患者中，外用前列腺素类似物比安慰剂具有更好的治疗效果和安全性.然而,实验治疗的最佳剂量和频率需要进一步研究。
