Abstract：
Biodegradable magnesium-based implants offer mechanical properties similar to natural bone, making them advantageous over nonbiodegradable metallic implants. However, monitoring the interaction between magnesium and tissue over time without interference is difficult. A noninvasive method, optical near-infrared spectroscopy, can be used to monitor tissue\'s functional and structural properties. In this paper, we collected optical data from an in vitro cell culture medium and in vivo studies using a specialized optical probe. Spectroscopic data were acquired over two weeks to study the combined effect of biodegradable Mg-based implant disks on the cell culture medium in vivo. Principal component analysis (PCA) was used for data analysis. In the in vivo study, we evaluated the feasibility of using the near-infrared (NIR) spectra to understand physiological events in response to magnesium alloy implantation at specific time points (Day 0, 3, 7, and 14) after surgery. Our results show that the optical probe can detect variations in vivo from biological tissues of rats with biodegradable magnesium alloy \"WE43\" implants, and the analysis identified a trend in the optical data over two weeks. The primary challenge of in vivo data analysis is the complexity of the implant interaction near the interface with the biological medium.
摘要：
可生物降解的镁基植入物提供与天然骨骼相似的机械性能，使它们优于不可生物降解的金属植入物。然而,在没有干扰的情况下监测镁和组织之间的相互作用是困难的。一种非侵入性方法，光学近红外光谱，可用于监测组织的功能和结构特性。在本文中,我们使用专门的光学探针从体外细胞培养基和体内研究中收集光学数据。在两周内获取光谱数据以研究可生物降解的基于Mg的植入物盘对体内细胞培养基的组合影响。采用主成分分析(PCA)进行数据分析。在体内研究中，我们评估了在手术后特定时间点(第0,3,7和14天)使用近红外(NIR)光谱了解镁合金植入术后生理事件的可行性.我们的结果表明，光学探针可以检测到体内生物组织的变化，从生物可降解镁合金\"WE43\"植入物，分析确定了两周内光学数据的趋势。体内数据分析的主要挑战是植入物与生物介质的界面附近相互作用的复杂性。
