Abstract：
Carnoy\'s solution, a chemical cauterisation agent, has been indicated as one of the adjuvant treatment modalities for odontogenic keratocyst. In 2000, after the ban of chloroform many surgeons adopted the use of Modified Carnoy\'s solution. The purpose of this study is to compare the depth of penetration and amount of bone necrosis of Carnoy\'s versus Modified Carnoy\'s solution on the mandible of Wistar rats at different time intervals. Twenty-six male Wistar rats of six to eight weeks old, weighing approximately 150-200 grams, were allocated for this study. The predictor variables were type of solution and application time. The outcome variable was depth of penetration and amount of bone necrosis. Carnoy\'s solution was applied on the defect on the right side of the mandible and Modified Carnoy\'s solution on the left side for five minutes on eight rats, eight minutes on eight rats, and 10 minutes on eight rats. All specimens were subjected to histomorphometric analysis done using Mia image AR software. Univariate ANOVA test, and paired sample t test was done to compare the results. The depth of penetration for Carnoy\'s solution was more than Modified Carnoy\'s solution in the three different exposure times. Statistically significant results were observed at five minutes and eight minutes. The amount of bone necrosis was more in Modified Carnoy\'s solution. The results were not statistically significant at the three different exposure times. To conclude, when one wants to use Modified Carnoy\'s solution, the minimum exposure time should be 10 minutes to achieve similar results as those of Carnoy\'s solution.
摘要：
Carnoy的解决方案,一种化学烧灼剂,已被证明是牙源性角化囊肿的辅助治疗方式之一。2000年，在禁止使用氯仿之后，许多外科医生采用了改良的Carnoy解决方案。本研究的目的是比较不同时间间隔的Carnoy\s和改良Carnoy\s溶液在Wistar大鼠下颌骨上的渗透深度和骨坏死量。二十六只六到八周大的雄性Wistar老鼠，重约150-200克,被分配给这项研究。预测变量是解决方案的类型和应用时间。结果变量为穿透深度和骨坏死量。在八只大鼠的下颌骨右侧的缺损上使用Carnoy溶液，在左侧的改良Carnoy溶液中使用五分钟，八只老鼠八分钟，八只老鼠10分钟。使用Mia图像AR软件对所有标本进行组织形态测量分析。单变量方差分析检验，并进行配对样本t检验以比较结果。在三种不同的暴露时间内，Carnoy溶液的渗透深度大于ModifiedCarnoy溶液的渗透深度。在5分钟和8分钟时观察到统计学上显著的结果。改良Carnoy溶液中的骨坏死量更多。结果在三个不同的暴露时间没有统计学意义。最后，当一个人想要使用ModifiedCarnoy\的解决方案时，最小暴露时间应为10分钟，以达到与Carnoy\的解决方案相似的结果。
