Abstract：
Here, an ethanol-mediated method was introduced to fabricate γ-cyclodextrin-based metal-organic frameworks (γ-CD-MOFs) as microcarriers for epigallocatechin-3-gallate (EGCG). Through adjusting ethanol gas diffusion temperature and ethanol liquid feed speed, we achieved control of crystallization efficiency and crystals size without extra surfactants. Under the sequential regulatory by ethanol in two phases, the obtained γ-CD-MOFs with cubic shape exhibited excellent crystallinity, high surface area, and uniform size distribution. Through the interplay of hydrogen bonding, hydrophobic interactions and π stacking, EGCG molecules could be stored efficiently within cavities and tunnels of the γ-CD-MOFs with high load capability of 334 mg g-1. More importantly, the incorporation of EGCG within frameworks wouldn\'t disintegrate the unique body-centered cubic structure of γ-CD-MOFs, in turn, would improve the thermostability and antioxidative activity of EGCG. Significantly, all food-grade materials ensured the γ-CD-MOFs high acceptance and applicability for food and biomedical applications.
摘要：
这里,引入乙醇介导的方法来制造γ-环糊精基金属有机骨架（γ-CD-MOFs）作为表没食子儿茶素-3-没食子酸酯（EGCG）的微载体。通过调节乙醇气体扩散温度和乙醇液体进料速度，我们实现了结晶效率和晶体尺寸的控制没有额外的表面活性剂。在乙醇分两个阶段的顺序监管下，所获得的具有立方形状的γ-CD-MOFs表现出优异的结晶度，高表面积,和均匀的尺寸分布。通过氢键的相互作用，疏水相互作用和π堆叠，EGCG分子可以有效地存储在γ-CD-MOF的空腔和隧道内，具有334mgg-1的高负载能力。更重要的是,EGCG在框架内的结合不会瓦解γ-CD-MOFs独特的体心立方结构，反过来,可以提高EGCG的热稳定性和抗氧化活性。重要的是,所有食品级材料确保了γ-CD-MOFs在食品和生物医学应用中的高接受度和适用性。
