Abstract：
Adult T-cell Leukemia/Lymphoma (ATLL) is a rapidly progressing type of T-cell non-Hodgkin lymphoma that is developed after the infection by human T-cell leukemia virus type 1 (HTLV-1). It could be categorized into four major subtypes, acute, lymphoma, chronic, and smoldering. These different subtypes have some shared clinical manifestations, and there are no trustworthy biomarkers for diagnosis of them.
We applied weighted-gene co-expression network analysis to find the potential gene and miRNA biomarkers for various ATLL subtypes. Afterward, we found reliable miRNA-gene interactions by identifying the experimentally validated-target genes of miRNAs.
The outcomes disclosed the interactions of miR-29b-2-5p and miR-342-3p with LSAMP in ATLL_acute, miR-575 with UBN2, miR-342-3p with ZNF280B, and miR-342-5p with FOXRED2 in ATLL_chronic, miR-940 and miR-423-3p with C6orf141, miR-940 and miR-1225-3p with CDCP1, and miR-324-3p with COL14A1 in ATLL_smoldering. These miRNA-gene interactions determine the molecular factors involved in the pathogenesis of each ATLL subtype and the unique ones could be considered biomarkers.
The above-mentioned miRNAs-genes interactions are suggested as diagnostic biomarkers for different ATLL subtypes.
We applied weighted-gene co-expression network analysis to find the potential gene and miRNA biomarkers for various ATLL subtypes. Afterward, we found reliable miRNA-gene interactions by identifying the experimentally validated-target genes of miRNAs.
The outcomes disclosed the interactions of miR-29b-2-5p and miR-342-3p with LSAMP in ATLL_acute, miR-575 with UBN2, miR-342-3p with ZNF280B, and miR-342-5p with FOXRED2 in ATLL_chronic, miR-940 and miR-423-3p with C6orf141, miR-940 and miR-1225-3p with CDCP1, and miR-324-3p with COL14A1 in ATLL_smoldering. These miRNA-gene interactions determine the molecular factors involved in the pathogenesis of each ATLL subtype and the unique ones could be considered biomarkers.
The above-mentioned miRNAs-genes interactions are suggested as diagnostic biomarkers for different ATLL subtypes.
摘要：
成人T细胞白血病/淋巴瘤（ATLL）是一种快速发展的T细胞非霍奇金淋巴瘤，是在1型人类T细胞白血病病毒（HTLV-1）感染后发展起来的。它可以分为四个主要亚型，急性,淋巴瘤慢性，阴燃。这些不同的亚型有一些共同的临床表现，并且没有可靠的生物标志物来诊断它们。
我们应用加权基因共表达网络分析来发现各种ATLL亚型的潜在基因和miRNA生物标志物。之后,我们通过鉴定经过实验验证的miRNA靶基因发现了可靠的miRNA-基因相互作用.
结果揭示了miR-29b-2-5p和miR-342-3p与LSAMP在ATLL_急性，miR-575与UBN2，miR-342-3p与ZNF280B，和miR-342-5p与FOXRED2在ATLL_慢性，miR-940和miR-423-3p与C6orf141，miR-940和miR-1225-3p与CDCP1，miR-324-3p与COL14A1在ATLL_闷烧中。这些miRNA-基因相互作用决定了每个ATLL亚型的发病机理中涉及的分子因素，并且独特的可以被认为是生物标志物。
上述miRNA-基因相互作用被认为是不同ATLL亚型的诊断生物标志物。
我们应用加权基因共表达网络分析来发现各种ATLL亚型的潜在基因和miRNA生物标志物。之后,我们通过鉴定经过实验验证的miRNA靶基因发现了可靠的miRNA-基因相互作用.
结果揭示了miR-29b-2-5p和miR-342-3p与LSAMP在ATLL_急性，miR-575与UBN2，miR-342-3p与ZNF280B，和miR-342-5p与FOXRED2在ATLL_慢性，miR-940和miR-423-3p与C6orf141，miR-940和miR-1225-3p与CDCP1，miR-324-3p与COL14A1在ATLL_闷烧中。这些miRNA-基因相互作用决定了每个ATLL亚型的发病机理中涉及的分子因素，并且独特的可以被认为是生物标志物。
上述miRNA-基因相互作用被认为是不同ATLL亚型的诊断生物标志物。
