We applied weighted-gene co-expression network analysis to find the potential gene and miRNA biomarkers for various ATLL subtypes. Afterward, we found reliable miRNA-gene interactions by identifying the experimentally validated-target genes of miRNAs.
The outcomes disclosed the interactions of miR-29b-2-5p and miR-342-3p with LSAMP in ATLL_acute, miR-575 with UBN2, miR-342-3p with ZNF280B, and miR-342-5p with FOXRED2 in ATLL_chronic, miR-940 and miR-423-3p with C6orf141, miR-940 and miR-1225-3p with CDCP1, and miR-324-3p with COL14A1 in ATLL_smoldering. These miRNA-gene interactions determine the molecular factors involved in the pathogenesis of each ATLL subtype and the unique ones could be considered biomarkers.
The above-mentioned miRNAs-genes interactions are suggested as diagnostic biomarkers for different ATLL subtypes.
我们应用加权基因共表达网络分析来发现各种ATLL亚型的潜在基因和miRNA生物标志物。之后,我们通过鉴定经过实验验证的miRNA靶基因发现了可靠的miRNA-基因相互作用.
结果揭示了miR-29b-2-5p和miR-342-3p与LSAMP在ATLL_急性,miR-575与UBN2,miR-342-3p与ZNF280B,和miR-342-5p与FOXRED2在ATLL_慢性,miR-940和miR-423-3p与C6orf141,miR-940和miR-1225-3p与CDCP1,miR-324-3p与COL14A1在ATLL_闷烧中。这些miRNA-基因相互作用决定了每个ATLL亚型的发病机理中涉及的分子因素,并且独特的可以被认为是生物标志物。
上述miRNA-基因相互作用被认为是不同ATLL亚型的诊断生物标志物。