PDF(Pubmed)
Abstract：
UNASSIGNED: The prevalence and treatment of severe scoliosis and other spinal anomalies in patients with Turner\'s syndrome (TS) is not well reported. This is the largest case series to date regarding the treatment course and outcomes of severely scoliotic TS patients.
UNASSIGNED: A retrospective chart review was performed to identify all patients with TS seen at a single center academic pediatric institution from 2007 to 2021. Of these, the presence of concomitant severe scoliosis or other spinal anomalies was determined, defined by a major coronal curve measuring 45° or greater. Demographic, clinical, surgical, and radiologic data was collected at both pre- and post-intervention time points.
UNASSIGNED: A retrospective chart review identified 306 patients with TS. Of those, six were identified to have severe scoliosis or other severe spinal anomalies requiring fusion. All four posterior spinal fusion (PSF) patients demonstrated improvement of their spinal curvature. One patient who electively pursued only bracing demonstrated minimal improvement and surgery was subsequently recommended, but not pursued. One patient expired from a pre-existing heart condition prior to intervention. All postoperative complications resolved with no further complications. The only brace-related complication was an allergic rash related to the brace material.
UNASSIGNED: All four patients who underwent PSF demonstrated significant improvement of their spinal curvature with few post-surgical complications. None of the patients in the bracing cohort demonstrated stabilization of their spinal curvature. Therefore, these data corroborate with prior studies, suggesting that operative management consisting of spinal fusion with instrumentation provides optimal clinical outcomes, compared to bracing only.
UNASSIGNED: A retrospective chart review was performed to identify all patients with TS seen at a single center academic pediatric institution from 2007 to 2021. Of these, the presence of concomitant severe scoliosis or other spinal anomalies was determined, defined by a major coronal curve measuring 45° or greater. Demographic, clinical, surgical, and radiologic data was collected at both pre- and post-intervention time points.
UNASSIGNED: A retrospective chart review identified 306 patients with TS. Of those, six were identified to have severe scoliosis or other severe spinal anomalies requiring fusion. All four posterior spinal fusion (PSF) patients demonstrated improvement of their spinal curvature. One patient who electively pursued only bracing demonstrated minimal improvement and surgery was subsequently recommended, but not pursued. One patient expired from a pre-existing heart condition prior to intervention. All postoperative complications resolved with no further complications. The only brace-related complication was an allergic rash related to the brace material.
UNASSIGNED: All four patients who underwent PSF demonstrated significant improvement of their spinal curvature with few post-surgical complications. None of the patients in the bracing cohort demonstrated stabilization of their spinal curvature. Therefore, these data corroborate with prior studies, suggesting that operative management consisting of spinal fusion with instrumentation provides optimal clinical outcomes, compared to bracing only.
摘要：
■特纳综合征（TS）患者严重脊柱侧凸和其他脊柱畸形的患病率和治疗方法尚未得到很好的报道。这是迄今为止关于严重脊柱侧弯TS患者的治疗过程和结果的最大病例系列。
■进行了回顾性图表审查，以确定2007年至2021年在单中心学术儿科机构中看到的所有TS患者。其中,确定是否存在伴随的严重脊柱侧凸或其他脊柱异常，由测量45°或更大的主要日冕曲线定义。人口统计,临床,外科,在干预前后时间点收集放射学数据.
■回顾性图表回顾确定了306例TS患者。其中,6人被确定患有严重脊柱侧凸或其他需要融合的严重脊柱畸形。所有四名后路脊柱融合术（PSF）患者均表现出脊柱弯曲度的改善。一名选择性仅进行支撑的患者表现出最小的改善，随后建议进行手术。但没有追求。一名患者在干预前从预先存在的心脏病中死亡。所有术后并发症均得到解决，无进一步并发症。唯一的支架相关并发症是与支架材料相关的过敏性皮疹。
■所有4例接受PSF治疗的患者均表现出脊柱曲度显著改善，术后并发症少。支撑队列中没有患者表现出脊柱弯曲稳定。因此,这些数据证实了先前的研究，提示由脊柱融合术和器械组成的手术管理提供了最佳的临床结果，与仅支撑相比。
■进行了回顾性图表审查，以确定2007年至2021年在单中心学术儿科机构中看到的所有TS患者。其中,确定是否存在伴随的严重脊柱侧凸或其他脊柱异常，由测量45°或更大的主要日冕曲线定义。人口统计,临床,外科,在干预前后时间点收集放射学数据.
■回顾性图表回顾确定了306例TS患者。其中,6人被确定患有严重脊柱侧凸或其他需要融合的严重脊柱畸形。所有四名后路脊柱融合术（PSF）患者均表现出脊柱弯曲度的改善。一名选择性仅进行支撑的患者表现出最小的改善，随后建议进行手术。但没有追求。一名患者在干预前从预先存在的心脏病中死亡。所有术后并发症均得到解决，无进一步并发症。唯一的支架相关并发症是与支架材料相关的过敏性皮疹。
■所有4例接受PSF治疗的患者均表现出脊柱曲度显著改善，术后并发症少。支撑队列中没有患者表现出脊柱弯曲稳定。因此,这些数据证实了先前的研究，提示由脊柱融合术和器械组成的手术管理提供了最佳的临床结果，与仅支撑相比。
