PDF(Pubmed)
Abstract：
To compare SARS-CoV-2 antibody seroprevalence among children with seropositive confirmed COVID-19 case counts (case ascertainment by molecular amplification) in Colorado, USA, we conducted a cross-sectional serosurvey during May-July 2021. For a convenience sample of 829 Colorado children, SARS-CoV-2 seroprevalence was 36.7%, compared with prevalence of 6.5% according to individually matched COVID-19 test results reported to public health. Compared with non-Hispanic White children, seroprevalence was higher among Hispanic, non-Hispanic Black, and non-Hispanic other race children, and case ascertainment was significantly lower among Hispanic and non-Hispanic Black children. This serosurvey accurately estimated SARS-CoV-2 prevalence among children compared with confirmed COVID-19 case counts and revealed substantial racial/ethnic disparities in infections and case ascertainment. Continued efforts to address racial and ethnic differences in disease burden and to overcome potential barriers to case ascertainment, including access to testing, may help mitigate these ongoing disparities.
摘要：
比较科罗拉多州血清阳性确诊COVID-19病例数（通过分子扩增确定病例数）儿童的SARS-CoV-2抗体血清阳性率，美国,我们在2021年5月至7月期间进行了横断面血清调查。为了方便829名科罗拉多州儿童的样本，SARS-CoV-2血清阳性率为36.7%,相比之下，根据向公共卫生报告的单独匹配的COVID-19检测结果，患病率为6.5%。与非西班牙裔白人儿童相比，血清阳性率在西班牙裔中较高，非西班牙裔黑人,和非西班牙裔其他种族的孩子，在西班牙裔和非西班牙裔黑人儿童中，病例确诊率显著较低。这项血清调查与确认的COVID-19病例数相比，准确估计了儿童中SARS-CoV-2的患病率，并揭示了感染和病例确定方面的重大种族/族裔差异。继续努力解决疾病负担中的种族和族裔差异，并克服病例确定的潜在障碍，包括进入测试，可能有助于缓解这些持续的差距。
