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Abstract：
Previous epidemiological studies have shown that both long-term and short-term exposure to fine particulate matters (PM2.5) were associated with the morbidity and mortality of circulatory system diseases (CSD). However, the impact of PM2.5 on CSD remains inconclusive. This study aimed to investigate the associations between PM2.5 and circulatory system diseases in Ganzhou.
We conducted this time series study to explore the association between ambient PM2.5 exposure and daily hospital admissions for CSD from 2016 to 2020 in Ganzhou by using generalized additive models (GAMs). Stratified analyses were also performed by gender, age, and season.
Based on 201,799 hospitalized cases, significant and positive associations were found between short-term PM2.5 exposure and hospital admissions for CSD, including total CSD, hypertension, coronary heart disease (CHD), cerebrovascular disease (CEVD), heart failure (HF), and arrhythmia. Each 10 μg/m3 increase in PM2.5 concentrations was associated with a 2.588% (95% confidence interval [CI], 1.161%-4.035%), 2.773% (95% CI, 1.246%-4.324%), 2.865% (95% CI, 0.786%-4.893%), 1.691% (95% CI, 0.239%-3.165%), 4.173% (95% CI, 1.988%-6.404%) and 1.496% (95% CI, 0.030%-2.983%) increment in hospitalizations for total CSD, hypertension, CHD, CEVD, HF, and arrhythmia, respectively. As PM2.5 concentrations rise, the hospitalizations for arrhythmia showed a slow upward trend, while other CSD increased sharply at high PM2.5 levels. In subgroup analyses, the impacts of PM2.5 on hospitalizations for CSD were not materially changed, although the females had higher risks of hypertension, HF, and arrhythmia. The relationships between PM2.5 exposure and hospitalizations for CSD were more significant among individuals aged ≤65 years, except for arrhythmia. PM2.5 had stronger effects on total CSD, hypertension, CEVD, HF, and arrhythmia during cold seasons.
PM2.5 exposure was positively associated with daily hospital admissions for CSD, which might provide informative insight on adverse effects of PM2.5.
We conducted this time series study to explore the association between ambient PM2.5 exposure and daily hospital admissions for CSD from 2016 to 2020 in Ganzhou by using generalized additive models (GAMs). Stratified analyses were also performed by gender, age, and season.
Based on 201,799 hospitalized cases, significant and positive associations were found between short-term PM2.5 exposure and hospital admissions for CSD, including total CSD, hypertension, coronary heart disease (CHD), cerebrovascular disease (CEVD), heart failure (HF), and arrhythmia. Each 10 μg/m3 increase in PM2.5 concentrations was associated with a 2.588% (95% confidence interval [CI], 1.161%-4.035%), 2.773% (95% CI, 1.246%-4.324%), 2.865% (95% CI, 0.786%-4.893%), 1.691% (95% CI, 0.239%-3.165%), 4.173% (95% CI, 1.988%-6.404%) and 1.496% (95% CI, 0.030%-2.983%) increment in hospitalizations for total CSD, hypertension, CHD, CEVD, HF, and arrhythmia, respectively. As PM2.5 concentrations rise, the hospitalizations for arrhythmia showed a slow upward trend, while other CSD increased sharply at high PM2.5 levels. In subgroup analyses, the impacts of PM2.5 on hospitalizations for CSD were not materially changed, although the females had higher risks of hypertension, HF, and arrhythmia. The relationships between PM2.5 exposure and hospitalizations for CSD were more significant among individuals aged ≤65 years, except for arrhythmia. PM2.5 had stronger effects on total CSD, hypertension, CEVD, HF, and arrhythmia during cold seasons.
PM2.5 exposure was positively associated with daily hospital admissions for CSD, which might provide informative insight on adverse effects of PM2.5.
摘要：
■先前的流行病学研究表明，长期和短期暴露于细颗粒物（PM2.5）与循环系统疾病（CSD）的发病率和死亡率有关。然而,PM2.5对CSD的影响尚无定论。本研究旨在探讨赣州市PM2.5与循环系统疾病的关系。
■我们进行了这项时间序列研究，以通过使用广义加性模型（GAMs）探讨2016年至2020年赣州CSD的环境PM2.5暴露与每日住院人数之间的关系。还按性别进行了分层分析，年龄,和季节。
■基于201,799例住院病例，发现短期PM2.5暴露与CSD住院之间存在显著和正相关，包括总CSD，高血压,冠心病,脑血管疾病（CEVD），心力衰竭(HF),和心律不齐。PM2.5浓度每增加10μg/m3与2.588%相关(95%置信区间[CI]，1.161%-4.035%），2.773%（95%CI，1.246%-4.324%），2.865%（95%CI，0.786%-4.893%），1.691%（95%CI，0.239%-3.165%），总CSD的住院率增加4.173％（95％CI，1.988％-6.404％）和1.496％（95％CI，0.030％-2.983％），高血压,CHD,CEVD,HF,和心律不齐,分别。随着PM2.5浓度的上升,心律失常的住院人数呈缓慢上升趋势,而其他CSD在PM2.5水平较高时急剧上升。在亚组分析中，PM2.5对CSD住院的影响没有实质性改变，尽管女性患高血压的风险更高，HF,和心律不齐。PM2.5暴露与CSD住院之间的关系在年龄≤65岁的个体中更为显著，除了心律失常.PM2.5对总CSD有更强的影响，高血压,CEVD,HF,和心律失常在寒冷的季节。
■PM2.5暴露与CSD的每日住院人数呈正相关，这可能会提供有关PM2.5不良反应的信息。
■我们进行了这项时间序列研究，以通过使用广义加性模型（GAMs）探讨2016年至2020年赣州CSD的环境PM2.5暴露与每日住院人数之间的关系。还按性别进行了分层分析，年龄,和季节。
■基于201,799例住院病例，发现短期PM2.5暴露与CSD住院之间存在显著和正相关，包括总CSD，高血压,冠心病,脑血管疾病（CEVD），心力衰竭(HF),和心律不齐。PM2.5浓度每增加10μg/m3与2.588%相关(95%置信区间[CI]，1.161%-4.035%），2.773%（95%CI，1.246%-4.324%），2.865%（95%CI，0.786%-4.893%），1.691%（95%CI，0.239%-3.165%），总CSD的住院率增加4.173％（95％CI，1.988％-6.404％）和1.496％（95％CI，0.030％-2.983％），高血压,CHD,CEVD,HF,和心律不齐,分别。随着PM2.5浓度的上升,心律失常的住院人数呈缓慢上升趋势,而其他CSD在PM2.5水平较高时急剧上升。在亚组分析中，PM2.5对CSD住院的影响没有实质性改变，尽管女性患高血压的风险更高，HF,和心律不齐。PM2.5暴露与CSD住院之间的关系在年龄≤65岁的个体中更为显著，除了心律失常.PM2.5对总CSD有更强的影响，高血压,CEVD,HF,和心律失常在寒冷的季节。
■PM2.5暴露与CSD的每日住院人数呈正相关，这可能会提供有关PM2.5不良反应的信息。
